2-[[5-(Aminomethyl)-4-hydroxy-3-sulfooxyoxolan-2-yl]oxy-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-6-hydroxy-1,4-dimethyl-3-oxo-1,4-diazepane-5-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[[5-(Aminomethyl)-4-hydroxy-3-sulfooxyoxolan-2-yl]oxy-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-6-hydroxy-1,4-dimethyl-3-oxo-1,4-diazepane-5-carboxylic acid
• 英文别名: 2-[[5-(aminomethyl)-4-hydroxy-3-sulfooxyoxolan-2-yl]oxy-[5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-6-hydroxy-1,4-dimethyl-3-oxo-1,4-diazepane-5-carboxylic acid
• 化学式: C₂₂H₃₃N₅O₁₆S
• 分子量: 655.6
• InChiKey: PUYIVEHGYMOTSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -10
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  317
• 氢给体数：
  8
• 氢受体数：
  18

文献信息

• CAPRAZENE-1'''-ESTERS AS ANTIBACTERIALS
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP2902403A1

  公开（公告）日：2015-08-05

  Caprazene-1"'-ester derivatives of the formula (III) wherein Me is methyl group, R2 is a straight chain or a substantially straight chain alkyl group of 5-21 carbon atoms or a straight chain or a substantially straight chain alkenyl group of 5-21 carbon atoms or an alkynyl group of 5-21 carbon atoms and A is hydrogen atom or an amino-protecting group which is an alkoxycarbonyl group or an aralkyloxycarbonyl group, or a pharmaceutically acceptable acid addition salt thereof. The novel caprazene derivatives exhibit excellent antibacterial activities against a variety of bacteria including acid-fast bacteria.

  式（III）的己二烯-1"'-酯衍生物 其中 Me 为甲基，R2 为 5-21 个碳原子的直链或大体直链烷基，或 5-21 个碳原子的直链或大体直链烯基，或 5-21 个碳原子的炔基，A 为氢原子或氨基保护基（烷氧基羰基或芳氧基羰基），或其药学上可接受的酸加成盐。 新型己二氮腙衍生物对包括耐酸细菌在内的多种细菌具有优异的抗菌活性。
• CAPRAZOL ESTERS AS ANTIBACTERIALS
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP2902404A1

  公开（公告）日：2015-08-05

  Caprazol-3"'-ester derivatives of the formula (VII) wherein Me is methyl group, R4 is a straight chain or a substantially straight chain alkyl group of 5-21 carbon atoms or a straight chain or a substantially straight chain alkenyl group of 5-21 carbon atoms or an alkynyl group of 5-21 carbon atoms and R5 is hydrogen atom or an alkyl group of 1-21 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof. The novel caprazol derivatives now synthesized exhibit excellent antibacterial activities against a variety of bacteria including acid-fast bacteria.

  式（VII）的己唑-3"'-酯衍生物 其中 Me 为甲基，R4 为 5-21 个碳原子的直链或大体直链烷基或 5-21 个碳原子的直链或大体直链烯基或 5-21 个碳原子的炔基，R5 为氢原子或 1-21 个碳原子的烷基，或其药学上可接受的酸加成盐。 现在合成的新型己唑醇衍生物对包括耐酸菌在内的多种细菌具有优异的抗菌活性。
• CAPRAZOL-1'''-AMIDES AS ANTIBACTERIALS
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP2902405A1

  公开（公告）日：2015-08-05

  Caprazol-1"'-amide derivatives of the formula (V) and caprazol-1"'- amide-3"'-ester derivatives from caprazol. The novel caprazol derivatives now synthesized exhibit excellent antibacterial activities against a variety of bacteria including acid-fast bacteria.

  式（V）的己二唑-1"'-酰胺衍生物和己二唑-1"'-酰胺-3"'-酯衍生物。 现在合成的新型己唑衍生物对包括耐酸菌在内的多种细菌具有出色的抗菌活性。
• 5"-N-ALKOXYCARBONYL OR 5"-N-ARALKYLOXYCARBONYL CAPRAZENE COMPOUNDS
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP3023432A1

  公开（公告）日：2016-05-25

  5"-N-alkoxycarbonyl and 5"-N-aralkyloxycarbonyl derivatives of caprazene, said caprazene being the compound represented by the following formula (I) wherein Me stands for methyl group.

  己二腈的 5"-N-烷氧基羰基和 5"-N-芳基氧基羰基衍生物，所述己二腈为下式 (I) 所代表的化合物 其中 Me 代表甲基。
• CAPRAZENE DERIVATIVE FOR THE SYNTHESIS OF ANTIBIOTICS
  申请人：ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI

  公开号：EP1593684B1

  公开（公告）日：2016-11-02