[(2S)-6-ethyl-4-methylmorpholin-2-yl]phosphane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: [(2S)-6-ethyl-4-methylmorpholin-2-yl]phosphane
• 化学式: C₇H₁₆NOP
• 分子量: 161.18
• InChiKey: HFWXVRQHRGYXKZ-MLWJPKLSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• MULTIPLE EXON SKIPPING COMPOSITIONS FOR DMD
  申请人：Sarepta Therapeutics, Inc.

  公开号：EP2350281B1

  公开（公告）日：2014-05-14
• ANTISENSE ANTIVIRAL COMPOUNDS AND METHODS FOR TREATING A FILOVIRUS INFECTION
  申请人：Sarepta Therapeutics, Inc.

  公开号：US20170306323A1

  公开（公告）日：2017-10-26

  The present invention provides antisense antiviral compounds, compositions, and methods of their use and production, mainly for inhibiting the replication of viruses of the Filoviridae family, including Ebola and Marburg viruses. The compounds, compositions, and methods also relate to the treatment of viral infections in mammals including primates by Ebola and Marburg viruses. The antisense antiviral compounds include phosphorodiamidate morpholino oligonucleotides (PMOplus) having a nuclease resistant backbone, about 15-40 nucleotide bases, at least two but typically no more than half piperazine-containing intersubunit linkages, and a targeting sequence that is targeted against the AUG start site region of Ebola virus VP35, Ebola virus VP24, Marburg virus VP24, or Marburg virus NP, including combinations and mixtures thereof.
• US9982261B2
  申请人：——

  公开号：US9982261B2

  公开（公告）日：2018-05-29