(R)-[(2S,5R)-5-ethenyl-5-methyl-1-azabicyclo[2.2.2]octan-2-yl]-[6-(hydroxymethyl)quinolin-4-yl]methanol

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: (R)-[(2S,5R)-5-ethenyl-5-methyl-1-azabicyclo[2.2.2]octan-2-yl]-[6-(hydroxymethyl)quinolin-4-yl]methanol
• 化学式: C₂₁H₂₆N₂O₂
• 分子量: 338.4
• InChiKey: OOMPXZQCQIWVPE-WMKHZRKJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  56.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Acridone Compounds
  申请人：Government of the United States of America dba The Department of Veterans Affairs

  公开号：US20140128423A1

  公开（公告）日：2014-05-08

  A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.
• ACRIDONE COMPOUNDS
  申请人：Oregon Health & Science University

  公开号：US20170144974A1

  公开（公告）日：2017-05-25

  A class of acridone compounds has been discovered that exhibits chemosensitizing and antiparasitic activity. Described herein are pharmaceutical compositions and methods for their use to treat parasitic infections, such as malaria and toxoplasmosis, and to sensitize resistant cells, such as multidrug resistant cells to other therapeutic agents. The pharmaceutical compositions and methods may also be used to treat and/or prevent psychotic diseases such as schizophrenia.
• US8987296B2
  申请人：——

  公开号：US8987296B2

  公开（公告）日：2015-03-24
• US9399625B2
  申请人：——

  公开号：US9399625B2

  公开（公告）日：2016-07-26