HSS-Lys-Leu-Gln-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: HSS-Lys-Leu-Gln-OH
• 英文别名: (2S)-5-amino-2-[[(2S)-2-[[(2S)-6-amino-2-(disulfanylamino)hexanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoic acid
• 化学式: C₁₇H₃₃N₅O₅S₂
• 分子量: 451.6
• InChiKey: FUEBAANNXMXHOQ-AVGNSLFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  203
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• PSA ENZYMATIC ACTIVITY: A NEW BIOMARKER FOR ASSESSING PROSTATE CANCER AGGRESSIVENESS
  申请人：NORTHWESTERN UNIVERSITY, AN ILLINOIS NOT FOR PROFIT CORPORATION

  公开号：US20140134658A1

  公开（公告）日：2014-05-15

  The disclosure provides for methods to determine prognosis, aggressiveness, and progression of prostate cancer with the ability to differentiate between aggressive and non-aggressive prostate cancer. The method utilizes the differential enzymatic activity in patient samples, for example of enzymatically active prostate specific antigen (PSA) activity, in order to determine the aggressiveness and prognosis of prostate cancer, and monitor the progression of prostate cancer therapy. The invention also encompasses assay platforms (e.g., optical or electrochemical) that specifically detect PSA-triggered peptide cleavage events.