Methyl 3-[2-[(3-methoxy-3-oxopropoxy)methyl]-3-(3-methylsulfonyloxypropoxy)-2-(3-methylsulfonyloxypropoxymethyl)propoxy]propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: Methyl 3-[2-[(3-methoxy-3-oxopropoxy)methyl]-3-(3-methylsulfonyloxypropoxy)-2-(3-methylsulfonyloxypropoxymethyl)propoxy]propanoate
• 英文别名: methyl 3-[2-[(3-methoxy-3-oxopropoxy)methyl]-3-(3-methylsulfonyloxypropoxy)-2-(3-methylsulfonyloxypropoxymethyl)propoxy]propanoate
• 化学式: C₂₁H₄₀O₁₄S₂
• 分子量: 580.7
• InChiKey: RJXQYXLXJBXZAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  37
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  193
• 氢给体数：
  0
• 氢受体数：
  14

文献信息

• MULTI-ARM POLYETHYLENE GLYCOL DERIVATIVES, CONJUGATES AND GELS OF PHARMACEUTICALS AND THE SAME
  申请人：JENKEM TECHNOLOGY CO., LTD, TIANJIN BRANCH

  公开号：US20140135486A1

  公开（公告）日：2014-05-15

  A multi-arm polyethylene glycol (I) having different kinds of reactive groups and the uses thereof are disclosed, which is formed by polymerizing ethylene oxide with oligo-pentaerythritol as an initiator, wherein, PEG is same or different and is —(CH2CH2O)m—, the average value of m is an integer of 2-250; l is an integer of 1 or more. The method for producing the multi-arm polyethylene glycol having different kinds of reactive groups, the multi-arm polyethylene glycol active derivatives comprising linking groups X attached to PEG and terminal reactive groups F attached to X, the gels formed by the multi-arm polyethylene glycol active derivatives, the drug conjugates formed by the multi-arm polyethylene glycol active derivatives and drug molecules, and the uses thereof in preparing drugs are also disclosed.