2-(11,13-Dioxo-1,4,7,10-tetrazacyclotridec-4-yl)acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(11,13-Dioxo-1,4,7,10-tetrazacyclotridec-4-yl)acetic acid
• 英文别名: 2-(11,13-dioxo-1,4,7,10-tetrazacyclotridec-4-yl)acetic acid
• 化学式: C₁₁H₂₀N₄O₄
• 分子量: 272.3
• InChiKey: LAJFZHUTLLPVRN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  111
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• NUCLEOTIDE AND PROTEIN SEQUENCES OF AN ANTIBODY DIRECTED AGAINST AN EPITOPE COMMON TO HUMAN ACIDIC AND BASIC FERRITINS, MONOCLONAL ANTIBODIES OR ANTIBODY-LIKE MOLECULES COMPRISING THESE SEQUENCES AND USE THEREOF
  申请人：IMMUNE PHARMACEUTICALS LTD.

  公开号：US20150071853A1

  公开（公告）日：2015-03-12

  The present invention is directed to monoclonal, chimeric or humanized, antibodies or antibody-like molecules that recognize an epitope common to human acidic and basic isoferritins. The anti-ferritin antibodies or antibody-like molecules can be used in pharmaceutical compositions for immunotherapy or radioimmunotherapy to target various cancer cells in a mammal. A method for delivering anti-ferritin antibodies or antibody-like molecules to cancerous lymph cells, pancreatic cells, lymphatic endothelium cells, and liver cells is also disclosed, as well as methods for treating pancreatic cancer, hepatocellular carcinomas, Kaposi's sarcoma and Hodgkin's lymphoma.
• US8728477B2
  申请人：——

  公开号：US8728477B2

  公开（公告）日：2014-05-20