N-(α-Dimethylphosphono-β-trichloraethyl)-acetamid | 42343-97-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 英文名称: N-(α-Dimethylphosphono-β-trichloraethyl)-acetamid
• 英文别名: (1-Acetylamino-2,2,2-trichloro-ethyl)-phosphonic acid dimethyl ester；N-(2,2,2-trichloro-1-dimethoxyphosphorylethyl)acetamide
• CAS: 42343-97-5
• 化学式: C₆H₁₁Cl₃NO₄P
• mdl: MFCD00181763
• 分子量: 298.49
• InChiKey: IJDXCQYFCRKZDM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(α-Dimethylphosphono-β-trichloraethyl)-acetamid 在 一水合肼 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 75.0h， 生成 (2-Methyl-5-{N'-[1-p-tolyl-meth-(E)-ylidene]-hydrazino}-oxazol-4-yl)-phosphonic acid dimethyl ester
  参考文献：
  名称：

  摘要：

  Treatment of 1-phosphorylated 2,2-dichloroethenylcarboxamides with excess hydrazine hydrate gives in high yields phosphorylated derivatives of 2-alkyl(aryl)-5-hydrazinooxazoles containing the P(O)(OCH3)(2), P(O)(OC2H5)(2), and P+(C6H5)3ClO(4)(-) groups in the 4-position of the ring. The presence of the hydrazine group in these oxazole derivatives was confirmed not only by the spectral data, but also by the reactions with p-toluic aldehyde, p-toluic chloride, and phenyl isothiocyanate.

  DOI：

  10.1023/a:1013982122431
• 作为产物：
  描述：

  N-(2,2,2-trichloroethylidene)acetamide 、 三甲氧基磷 以 乙醚 为溶剂， 生成 N-(α-Dimethylphosphono-β-trichloraethyl)-acetamid
  参考文献：
  名称：

  Structure of reaction products of trimethyl phosphite with N-acetyltrichloroacetaldimine

  摘要：

  DOI：

  10.1007/bf00854251

文献信息

• ——
  作者：V. S. Brovarets、R. N. Vydzhak、S. G. Pil'o、K. V. Zyuz'、B. S. Drach

  DOI：10.1023/a:1013982122431

  日期：——

  Treatment of 1-phosphorylated 2,2-dichloroethenylcarboxamides with excess hydrazine hydrate gives in high yields phosphorylated derivatives of 2-alkyl(aryl)-5-hydrazinooxazoles containing the P(O)(OCH3)(2), P(O)(OC2H5)(2), and P+(C6H5)3ClO(4)(-) groups in the 4-position of the ring. The presence of the hydrazine group in these oxazole derivatives was confirmed not only by the spectral data, but also by the reactions with p-toluic aldehyde, p-toluic chloride, and phenyl isothiocyanate.
• Structure of reaction products of trimethyl phosphite with N-acetyltrichloroacetaldimine
  作者：B. A. Arbuzov、N. A. Polezhaeva、V. S. Vinogradova

  DOI：10.1007/bf00854251

  日期：1973.5