N-tert-butyl-2-((Z)-3-benzylidene-2-oxoindolin-1-yl)-2-(3-nitrophenyl)acetamide | 1346242-19-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-tert-butyl-2-((Z)-3-benzylidene-2-oxoindolin-1-yl)-2-(3-nitrophenyl)acetamide
• 英文别名: 2-[(3Z)-3-benzylidene-2-oxoindol-1-yl]-N-tert-butyl-2-(3-nitrophenyl)acetamide
• CAS: 1346242-19-0
• 化学式: C₂₇H₂₅N₃O₄
• 分子量: 455.513
• InChiKey: KJVKJOTYYUJLKE-JWGURIENSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  95.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-[2-(tert-butylamino)-1-(3-nitrophenyl)-2-oxoethyl]-N,3-diphenylprop-2-ynamide 在 碘苯 、 palladium diacetate 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 以20%的产率得到N-tert-butyl-2-((Z)-3-benzylidene-2-oxoindolin-1-yl)-2-(3-nitrophenyl)acetamide
  参考文献：
  名称：

  Pd-catalyzed synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles

  摘要：

  An efficient method for the stereoselective synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles via carbopalladation is described. In this approach. an Ugi-4-component reaction (4-CR) adduct was used as the starting material. A one-pot sequence involving intermolecular carbopalladation C-H activation/C-C bond formation efficiently afforded the oxindole derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.089

文献信息

• Pd-catalyzed synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles
  作者：Saeed Balalaie、Hassan Motaghedi、Morteza Bararjanian、Daryoush Tahmassebi、Hamid Reza Bijanzadeh

  DOI：10.1016/j.tet.2011.09.089

  日期：2011.11

  An efficient method for the stereoselective synthesis of 3-(diarylmethylene)-2-oxindoles and 3-(arylmethylene)-2-oxindoles via carbopalladation is described. In this approach. an Ugi-4-component reaction (4-CR) adduct was used as the starting material. A one-pot sequence involving intermolecular carbopalladation C-H activation/C-C bond formation efficiently afforded the oxindole derivatives. (C) 2011 Elsevier Ltd. All rights reserved.