(2,5-Dioxopyrrolidin-1-yl) 4-[1,7-bis(methylamino)-1,7-dioxoheptan-4-yl]oxybutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 4-[1,7-bis(methylamino)-1,7-dioxoheptan-4-yl]oxybutanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 4-[1,7-bis(methylamino)-1,7-dioxoheptan-4-yl]oxybutanoate
• 化学式: C₁₇H₂₇N₃O₇
• 分子量: 385.4
• InChiKey: FJTGFLXMAQBPPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  27
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• NUCLEIC ACID MODULATORS OF GLYCOPROTEIN VI
  申请人：REGADO BIOSCIENCES, INC.

  公开号：US20140128454A1

  公开（公告）日：2014-05-08

  The present invention relates, in general, to a pharmacologic system to modulate the biology of platelets based upon a nucleic acid ligand that can interact with and modulate the activity of platelet glycoprotein GPVI to regulate platelet function. These nucleic acid ligands are also actively reversible using a modulator that inhibits the activity of the nucleic acid ligand to neutralize this pharmacologic effect and thereby restore GPVI function, including collagen binding, platelet adhesion, collagen-induced platelet activation, and collagen-induced platelet aggregation. The invention further relates to compositions comprising the nucleic acid ligand, the ligand and a modulator, methods to generate the nucleic acid ligand and its modulator, as well as methods of using these agents and compositions in medical therapeutic and diagnostic procedures.