cyclo[Aoda-Trp(OMe)-DL-Val-D-Pip]

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cyclo[Aoda-Trp(OMe)-DL-Val-D-Pip]
• 英文别名: (6S,9S,12R)-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-3-propan-2-yl-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone
• 化学式: C₃₃H₄₇N₅O₆
• 分子量: 609.8
• InChiKey: GWLHFNKLJRZBAI-VOJLBNOVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  44
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  139
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME<br/>[FR] INHIBITEURS D'HISTONE DÉSACÉTYLASES ET PROCÉDÉS THÉRAPEUTIQUES LES UTILISANT
  申请人：UNIV ILLINOIS

  公开号：WO2017040564A1

  公开（公告）日：2017-03-09

  Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed

  组蛋白去乙酰化酶抑制剂（HDACIs）及其包含该抑制剂的组合物被公开。还公开了治疗疾病和状况的方法，其中抑制HDAC可带来益处，例如癌症、神经退行性疾病、周围神经病变、神经系统疾病、创伤性脑损伤、中风、高血压、疟疾、自身免疫疾病、孤独症、孤独症谱系障碍和炎症。
• HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME
  申请人：Kozikowski Alan

  公开号：US20140128408A1

  公开（公告）日：2014-05-08

  Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

  本发明公开了组蛋白去乙酰化酶抑制剂（HDACIs）及其组成物。公开了治疗疾病和状况的方法，其中抑制HDAC提供了益处，如癌症、神经退行性疾病、周围神经病变、神经疾病、创伤性脑损伤、中风、高血压、疟疾、自身免疫疾病、自闭症、自闭症谱系障碍和炎症。
• HDAC inhibitors and therapeutic methods using the same
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：US10836733B2

  公开（公告）日：2020-11-17

  Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

  本发明公开了组蛋白去乙酰化酶抑制剂（HDACIs）和含有HDACIs的组合物。此外，还公开了治疗癌症、神经退行性疾病、周围神经病变、神经系统疾病、创伤性脑损伤、中风、高血压、疟疾、自身免疫性疾病、自闭症、自闭症谱系障碍和炎症等HDAC抑制剂可带来益处的疾病和病症的方法。
• Nrf and HIF activators/HDAC inhibitors and therapeutic methods using the same
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：US10934255B2

  公开（公告）日：2021-03-02

  Compounds that inhibit histone (HDACI) and/or activate Nrf2 and HIF, and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC and/or activation of Nrf2 and HIF provide a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.

  本发明公开了抑制组蛋白（HDACI）和/或激活Nrf2和HIF的化合物，以及含有这些化合物的组合物。此外，还公开了抑制 HDAC 和/或激活 Nrf2 和 HIF 可使癌症、神经退行性疾病、周围神经病变、神经系统疾病、脑外伤、中风、高血压、疟疾、自身免疫性疾病、自闭症、自闭症谱系障碍和炎症等疾病和病症受益的治疗方法。
• HDAC Inhibitors and Therapeutic Methods Using the Same
  申请人：THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

  公开号：US20190023670A1

  公开（公告）日：2019-01-24

  Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed