4-[(3Z)-penta-1,3-dien-2-yl]morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-[(3Z)-penta-1,3-dien-2-yl]morpholine
• 化学式: C₉H₁₅NO
• 分子量: 153.22
• InChiKey: JXNYDXCZYMYISI-ARJAWSKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] ALKYL-AMIDE-SUBSTITUTED PYRIDYL COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFNα RESPONSES<br/>[FR] COMPOSÉS PYRIDYLE SUBSTITUÉS PAR ALKYL-AMIDE, UTILES COMME MODULATEURS D'IL-12, IL-23 ET/OU DE RÉPONSES À L'IFN&Agr;
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014074660A1

  公开（公告）日：2014-05-15

  Compounds having the following formula (I): or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.

  具有以下化学式（I）的化合物，或其立体异构体或药用可接受盐，其中R1、R2、R3、R4和R5如本文所定义，在通过作用于Tyk-2引起信号转导抑制的过程中，对IL-12、IL-23和/或IFNα的调节是有用的。
• CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY
  申请人：CERULEAN PHARMA INC.

  公开号：US20130196945A1

  公开（公告）日：2013-08-01

  The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

  本发明涉及一种新型治疗环糊精含聚合物组成物，其设计为小分子治疗药物传递的载体以及其制药组合物。这些含环糊精聚合物可提高药物稳定性和溶解度，并在体内使用时减少小分子治疗药物的毒性。此外，通过从各种连接基团和靶向配体中进行选择，这些聚合物提供了治疗剂的控制释放方法。本发明还涉及使用所述治疗组成物治疗受试者的方法。本发明还涉及用于进行制药业务的方法，包括制造、许可或分发包含或涉及所述聚合物化合物的工具包。
• COMPOUNDS ACTIVE TOWARDS BROMODOMAINS
  申请人：NUEVOLUTION A/S

  公开号：US20170349607A1

  公开（公告）日：2017-12-07

  Disclosed are compounds towards bromodomains, pharmaceutical compositions containing the compounds and use of the compounds in therapy.
• [EN] ARTIFICIAL SELF-SUFFICIENT CYTOCHROME P450S<br/>[FR] CYTOCHROMES P450 AUTOSUFFISANTS ARTIFICIELS
  申请人：UNIV FLORIDA

  公开号：WO2016134145A9

  公开（公告）日：2017-02-16

  [EN] The disclosure relates to the field of fusion proteins. In some aspects, the invention relates to artificial fusion proteins comprising cytochrome P450 enzymes linked to reductase enzymes and uses thereof. In some aspects, the disclosure relates to compounds produced by artificial cytochrome P450 enzymes.
  [FR] La présente invention se rapporte au domaine des protéines hybrides. Dans certains aspects, l'invention concerne des protéines hybrides artificielles comprenant des enzymes du cytochrome P450 liées à des enzymes réductase et leurs utilisations. Dans certains aspects, l'invention concerne des composés produits par des enzymes du cytochrome P450 artificielles.