N-[(2S,4R)-4-benzyl-2-hydroxy-5-morpholin-4-yl-5-oxopentyl]-4-nitrobenzenesulfonamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(2S,4R)-4-benzyl-2-hydroxy-5-morpholin-4-yl-5-oxopentyl]-4-nitrobenzenesulfonamide
• 化学式: C22H27N3O7S
• 分子量: 477.5
• InChiKey: KMZSAQDUQMOMDY-QUCCMNQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  33
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• INHIBITORS OF CENTRAL NERVOUS SYSTEM VASOACTIVE INHIBITORY PEPTIDE RECEPTOR 2
  申请人：The Trustees Of Columbia University In The City Of New York

  公开号：US20150239831A1

  公开（公告）日：2015-08-27

  The present invention relates to compounds that inhibit VIPR 2 in the CNS, pharmaceutical compositions comprising said compounds, and methods of using such compounds and compositions in the treatment of a CNS disorder such as a behavioral disorder, including but not limited to schizophrenia.
• [EN] INHIBITORS OF CENTRAL NERVOUS SYSTEM VASOACTIVE INHIBITORY PEPTIDE RECEPTOR 2<br/>[FR] INHIBITEURS DU RÉCEPTEUR 2 DE PEPTIDE INHIBITEUR VASO-ACTIF DU SYSTÈME NERVEUX CENTRAL
  申请人：UNIV COLUMBIA

  公开号：WO2014075096A1

  公开（公告）日：2014-05-15

  The present invention relates to compounds that inhibit VIPR2 in the CNS, pharmaceutical compositions comprising said compounds, and methods of using such compounds and compositions in the treatment of a CNS disorder such as a behavioral disorder, including but not limited to schizophrenia.