4-Cyano-4-methylsulfanylcarbothioylsulfanylpentanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-Cyano-4-methylsulfanylcarbothioylsulfanylpentanoic acid
• 英文别名: 4-cyano-4-methylsulfanylcarbothioylsulfanylpentanoic acid
• 化学式: C₈H₁₁NO₂S₃
• 分子量: 249.4
• InChiKey: OFWCQNGTOCCGMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  144
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• HYDROPHILIC NANOSTRUCTURED MEMBRANE ACTIVE ANTIMICROBIALS WITH HIGH ACTIVITY, SELECTIVITY AND BIODEGRADABILITY
  申请人：Texas Tech University System

  公开号：US20190231703A1

  公开（公告）日：2019-08-01

  The present invention includes compositions and methods of making hydrophilic nanostructured antibiotics (i.e. nanoantibiotics), including nanoantibiotics that use environmentally degradable biomolecules as the backbone building blocks, wherein the backbone building blocks can include spherical backbones such as sucroses, cyclodextrins, glycogens, and phytoglycogen with different diameters, or rod-like backbone building blocks such as dextrins, amyloses, and celluloses with different lengths. These hydrophilic nanoantibiotics with well-defined sizes and shapes can selectively disrupt bacterial membranes (i.e., serve as membrane-active antimicrobials) while being benign to mammalian cells. Depending on the size and shape difference of the hydrophilic nanoantibiotics, they can also selectively kill one type of bacteria (e.g., gram-negative) over another type (e.g., gram-positive). The environmentally degradable nanoantibiotics will have built-in dismantling “switches” to dismantle and become antimicrobial inactive in responsive to environmental stimuli once released into natural habitat, hence greatly reducing the possibility of developing bacteria resistance.

  本发明涵盖了制备亲水性纳米结构抗生素（即纳米抗生素）的组合物和方法，包括使用环境可降解生物分子作为骨架构建块的纳米抗生素，其中骨架构建块可以包括球形骨架，如蔗糖、环糊精、糖原和植物糖原，直径不同，或者类似棒状的骨架构建块，如糊精、淀粉和纤维素，长度不同。这些具有明确定义大小和形状的亲水性纳米抗生素可以选择性地破坏细菌膜（即作为膜活性抗菌剂），同时对哺乳动物细胞无害。根据亲水性纳米抗生素的大小和形状差异，它们还可以选择性地杀死一种类型的细菌（例如革兰氏阴性菌），而不影响另一种类型（例如革兰氏阳性菌）。环境可降解的纳米抗生素将具有内置的拆除“开关”，一旦释放到自然栖息地中，将对环境刺激做出反应并迅速失活，从而大大降低细菌抗药性的可能性。
• [EN] POLYAMINE PRODRUGS AND POLYAMINE PRODRUG FORMULATIONS<br/>[FR] PROMÉDICAMENTS DE POLYAMINE ET FORMULATIONS DE PROMÉDICAMENT DE POLYAMINE
  申请人：UNIV NEBRASKA

  公开号：WO2019173446A1

  公开（公告）日：2019-09-12

  Provided herein are copolymers comprising monomers of a polyamine and a degradable linker, and further comprising a stabilizing moiety, a fluorinated moiety, a poly(ethylene glycol) (PEG) which is optionally substituted with a targeting moiety, or a combination thereof. Also provided are nanoparticles comprising copolymers as described herein, and methods of using the copolymers and nanoparticles for treating diseases or disorders, e.g., Snyder Robinson Disease or cancer.

  本文提供了由聚胺和可降解连接剂单体组成的共聚物，进一步包括稳定基团、氟化基团、聚乙二醇（PEG），可选择用靶向基团替代，或其组合。本文还提供了包括上述共聚物的纳米粒子，并提供了使用这些共聚物和纳米粒子治疗疾病或疾病的方法，例如Snyder Robinson病或癌症。
• Poly (meth)acrylate with improved viscosity index for lubricant additive application
  申请人：Afton Chemical Corporation

  公开号：US10351792B2

  公开（公告）日：2019-07-16

  The present disclosure relates to polymers suitable for viscosity index improvers in lubricating oil compositions and further relates to oil compositions comprising such polymers. The disclosure also relates to polymer compositions derived from alkyl (meth)acrylate monomers and selected molar ratios of the (meth)acrylate monomers in the polymer suitable to use as viscosity modifiers.

  本公开涉及适用于润滑油组合物粘度指数改进剂的聚合物，还涉及包含此类聚合物的润滑油组合物。本公开还涉及由(甲基)丙烯酸烷基单体衍生的聚合物组合物，以及聚合物中适合用作粘度调节剂的(甲基)丙烯酸单体的选定摩尔比。
• Photoresist composition and photoresist film using the same
  申请人：LG CHEM, LTD.

  公开号：US10990009B2

  公开（公告）日：2021-04-27

  A photoresist composition capable of forming a pattern in which a footing phenomenon is suppressed while being highly sensitive during formation of a fine pattern on a metal surface substrate, and capable of producing a photoresist film that is excellent in chemical stability, and a photoresist film using the photoresist composition.

  一种光刻胶组合物，它能在金属表面基底上形成精细图案时抑制脚底现象，同时具有高灵敏度，并能生成化学稳定性极佳的光刻胶膜，以及使用该光刻胶组合物的光刻胶膜。
• Radical cascade-enabled synthesis of precision polymers with complex main-chain structures
  申请人：Trustees of Boston College

  公开号：US11186678B2

  公开（公告）日：2021-11-30

  Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  本研究提供了可实现序列控制的开环聚合和开环聚合的自由基级联反应，用于受控合成具有复杂主链结构的聚合物。此外，还提供了简便的合成方法，从而获得由开环触发器和扩展主链结构组成的低应变大环单体。本公开进一步提供了对聚合物分子量和分子量分布进行出色控制的方法，高链端保真度使得制备具有明确结构的聚合物体系成为可能。此外，还提供了聚合物化学中自由基级联触发转化的一般性质，及其在合成具有定制功能的各种主链结构基团的聚合物中的应用。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本公开内容的限制。