(2R,3R,4S,5R)-3-[(2R,3R,4S,5R)-3,5-dihydroxy-2-(hydroxymethyl)-4-(3-hydroxy-5-nonoxyanilino)oxan-3-yl]sulfanyl-2-(hydroxymethyl)-4-(3-hydroxy-5-nonoxyanilino)oxane-3,5-diol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (2R,3R,4S,5R)-3-[(2R,3R,4S,5R)-3,5-dihydroxy-2-(hydroxymethyl)-4-(3-hydroxy-5-nonoxyanilino)oxan-3-yl]sulfanyl-2-(hydroxymethyl)-4-(3-hydroxy-5-nonoxyanilino)oxane-3,5-diol
• 化学式: C₄₂H₆₈N₂O₁₂S
• 分子量: 825.1
• InChiKey: RYXXKIBYSDUSCU-JJJFCCKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  57
• 可旋转键数：
  26
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  248
• 氢给体数：
  10
• 氢受体数：
  15

文献信息

• [EN] METHODS, COMPOSITIONS AND KITS FOR TREATING, MODULATING, OR PREVENTING OCULAR ANGIOGENESIS OR FIBROSIS IN A SUBJECT USING A GALECTIN PROTEIN INHIBITOR<br/>[FR] MÉTHODES, COMPOSITIONS ET KITS DE TRAITEMENT, DE MODULATION OU DE PRÉVENTION DE L'ANGIOGENÈSE OU DE LA FIBROSE OCULAIRE CHEZ UN SUJET UTILISANT UN INHIBITEUR DE GALECTINE
  申请人：UNIV TUFTS

  公开号：WO2014078655A1

  公开（公告）日：2014-05-22

  Methods and kits using a pharmaceutical composition for use in inhibiting ocular angiogenesis or fibrosis are provided herein, such that composition includes a pharmaceutically suitable carrier or diluent and an amount of the inhibitor composition effective to inhibit the angiogenesis or the fibrosis by inhibiting expression and/or activity of a galectin protein or a portion thereof.

  本文提供了用于抑制眼部血管生成或纤维化的制药组合物的方法和试剂盒，该组合物包括一种药用合适载体或稀释剂和足以抑制血管生成或纤维化的抑制剂组合物的数量，通过抑制表达和/或活性的低聚半乳糖蛋白或其部分来抑制血管生成或纤维化。
• METHODS, COMPOSITIONS AND KITS FOR TREATING, MODULATING, OR PREVENTING OCULAR ANGIOGENESIS OR FIBROSIS IN A SUBJECT USING A GALECTIN PROTEIN INHIBITOR
  申请人：Tufts University

  公开号：EP2919802A1

  公开（公告）日：2015-09-23
• CHEMICALS AND THE SYNTHESIZING METHODS THEREOF
  申请人：Cheng Yen-Ju

  公开号：US20130237676A1

  公开（公告）日：2013-09-12

  A series of ladder-type multifused arenes (hexacyclic, heptacyclic and nonacyclic units) and the synthesizing methods thereof are provided. The ladder-type multifused arenes are copolymerized with various electron-deficient acceptor units to afford various p-type low-band gap conjugated copolymers.