(1S,5S,8R,11R)-7-tert-butyl-7,11-dihydroxy-4,9,13-trioxatricyclo[6.3.2.01,5]tridecane-3,10,12-trione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (1S,5S,8R,11R)-7-tert-butyl-7,11-dihydroxy-4,9,13-trioxatricyclo[6.3.2.01,5]tridecane-3,10,12-trione
• 化学式: C₁₄H₁₈O₈
• 分子量: 314.29
• InChiKey: OWNYYTZOHDIWBH-JMBRCORXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• PHARMACOLOGICAL TREATMENT OF COGNITIVE IMPAIRMENT
  申请人：The Board of Trustees of the Leland Stanford Junior University

  公开号：US20140296210A1

  公开（公告）日：2014-10-02

  Methods for treating an individual to improve cognitive function are provided. In the subject methods, an effective amount of a noncompetitive GABA A ionophore blocker is administered to the individual, resulting in an improvement in cognitive function of the host. The subject methods find use in a variety of different applications.
• US8729067B2
  申请人：——

  公开号：US8729067B2

  公开（公告）日：2014-05-20