7-[(1R,2R)-2-(3-hydroxy-4-phenylbutyl)-6-oxocyclohexyl]heptanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-[(1R,2R)-2-(3-hydroxy-4-phenylbutyl)-6-oxocyclohexyl]heptanoic acid
• 化学式: C₂₃H₃₄O₄
• 分子量: 374.5
• InChiKey: LYYFFKPALVMBBX-GIBKCMNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SKIN WOUND HEALING AND SCAR REDUCTION WITH PROSTAGLANDIN EP4 AGONIST COMBINATIONS
  申请人：Allergan, Inc.

  公开号：US20140142042A1

  公开（公告）日：2014-05-22

  A combination of a prostaglandin EP4 agonist and an effective amount of: a prostaglandin EP2 agonist, a skin growth factor, a small peptide, a small inhibitory RNA targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine A2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars.
• COMPOUNDS AND METHODS FOR SKIN REPAIR
  申请人：Allergan, Inc.

  公开号：US20140142092A1

  公开（公告）日：2014-05-22

  The disclosure provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one mixed EP2/EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like.
• [EN] COMPOUNDS AND METHODS FOR SKIN REPAIR<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR LA RÉPARATION DE LA PEAU
  申请人：ALLERGAN INC

  公开号：WO2014078434A1

  公开（公告）日：2014-05-22

  The disclosure provides compositions and methods for wound healing and scar reduction. The compositions and methods of the invention include at least one mixed EP2/EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like.
• [EN] SKIN WOUND HEALING AND SCAR REDUCTION WITH PROSTAGLANDIN EP4 AGONIST COMBINATIONS<br/>[FR] CICATRISATION D'UNE BLESSURE DE LA PEAU ET RÉDUCTION DE LA CICATRICE PAR DES COMBINAISONS D'AGONISTE DE PROSTAGLANDINE EP4
  申请人：ALLERGAN INC

  公开号：WO2014078446A2

  公开（公告）日：2014-05-22

  A combination of a prostaglandin EP4 agonist and an effective amount of : a prostaglandin EP2 agonist, a skin growth factor, a small peptide, a small inhibitory RNA targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine A2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars.