(6aS)-3-[5-[[(6aS)-2-methyl-8-(4-methylphenyl)-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]pentoxy]-2-methoxy-8-(4-methylphenyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: (6aS)-3-[5-[[(6aS)-2-methyl-8-(4-methylphenyl)-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]pentoxy]-2-methoxy-8-(4-methylphenyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• 化学式: C₄₅H₄₄N₄O₅
• 分子量: 720.9
• InChiKey: GZBABWWBHSGTHK-ZPGRZCPFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  54
• 可旋转键数：
  11
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  93
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• UNSYMMETRICAL PYRROLOBENZODIAZEPINE-DIMERS FOR TREATMENT OF PROLIFERATIVE DISEASES
  申请人：SPIROGEN SARL

  公开号：US20140142090A1

  公开（公告）日：2014-05-22

  The present invention is directed to novel pyrrolobenzodiazepine dimers and methods of using the dimers in the treatment of proliferative diseases.

  本发明涉及新型吡咯苯并二氮杂环双聚体及其在治疗增殖性疾病中的使用方法。
• ACTIVATED CARBON FILTRATION FOR PURIFICATION OF BENZODIAZEPINE ADCS
  申请人：SEATTLE GENETICS, INC.

  公开号：US20160039870A1

  公开（公告）日：2016-02-11

  Disclosed are methods of purifying mixtures comprising benzoidiazepine antibody-drug conjugates.
• CYCLODEXTRIN AND ANTIBODY-DRUG CONJUGATE FORMULATIONS
  申请人：SEATTLE GENETICS, INC.

  公开号：US20170232112A1

  公开（公告）日：2017-08-17

  Disclosed are formulations, including both liquid and lyophilized formulations, comprising a benzodiazepine antibody-drug conjugate (ADC) and a cyclodextrin. Also disclosed are methods of purifying mixtures comprising benzodiazepine antibody-drug conjugates and process drug-related impurities.
• US8940733B2
  申请人：——

  公开号：US8940733B2

  公开（公告）日：2015-01-27
• US9453046B2
  申请人：——

  公开号：US9453046B2

  公开（公告）日：2016-09-27