5-甲基-1,2,3,4-苯四胺 | 780719-70-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-甲基-1,2,3,4-苯四胺
• 中文别名: 1,2,3,4-苯四胺,5-甲基-
• 英文名称: 5-methyl-1,2,3,4-benzenetetramine
• 英文别名: 5-methyl-benzene-1,2,3,4-tetrayltetraamine；5-Methyl-benzen-1,2,3,4-tetrayltetraamin；2.3.4.5-Tetraamino-1-methyl-benzol；2.3.4.5-Tetraamino-toluol；5-Methylbenzene-1,2,3,4-tetramine
• CAS: 780719-70-2
• 化学式: C₇H₁₂N₄
• 分子量: 152.199
• InChiKey: UYWUWZYTBYXIIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-甲基-1,2,3,4-苯四胺 在 硫酸 作用下， 生成 (5-methyl-pyrazino[2,3-f]quinoxaline-2,3,8,9-tetrayl)-tetra-acetic acid tetraethyl ester
  参考文献：
  名称：

  Thomas-Mamert; Striebel, Bulletin de la Societe Chimique de France, 1901, vol. <3>25, p. 720

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二乙酰基氨基甲苯 在 盐酸 、 硝酸 、 tin(ll) chloride 作用下， 生成 5-甲基-1,2,3,4-苯四胺
  参考文献：
  名称：

  Nietzki; Roesel, Chemische Berichte, 1890, vol. 23, p. 3217

  摘要：

  DOI：

文献信息

• Sulfur Nitrides in Organic Chemistry. 18. Preparation and Reduction of Benzo[1,2-<i>c</i>:3,4-<i>c</i>′:5,6-<i>c</i>″]tris- and Benzo[1,2-<i>c</i>:3,4-<i>c</i>′]bis[1,2,5]thiadiazole. A Convenient Route to Benzenehexamine and 1,2,3,4-Benzenetetramine
  作者：Shuntaro Mataka、Hisao Eguchi、Kazufumi Takahashi、Taizo Hatta、Masashi Tashiro

  DOI：10.1246/bcsj.62.3127

  日期：1989.10

  Benzotris- (3) and benzobis[1,2,5]thiadiazole (4) were prepared in a moderate yield, respectively, by the reaction of tetrasulfur tetranitride (5) with halocatechols (6) and -resorcinols (7). The reduction of 3 and 4 with Sn powder in a mixture of concentrated hydrochloric acid and dioxane gave benzenehexamine (1) and 1,2,3,4-benzenetetramine (2a) and its 5-methyl derivative (2b) in good yields, as

  通过四氮化四硫 (5) 与卤代儿茶酚 (6) 和间苯二酚 (7) 的反应，分别以中等产率制备苯并三- (3) 和苯并双 [1,2,5] 噻二唑 (4)。在浓盐酸和二恶烷的混合物中用锡粉还原 3 和 4 得到苯六胺 (1) 和 1,2,3,4-苯四胺 (2a) 及其 5-甲基衍生物 (2b)，收率良好，如分别是稳定的三盐酸盐 (1·3HCl) 和二盐酸盐 (2·2HCl)。
• [EN] NLRP3 ACTIVATORS FOR USE IN THE TREATMENT OF INFECTIOUS DISEASES OR CANCER BY ACTIVATING NLRP3 INFLAMMASOME<br/>[FR] ACTIVATEURS DE NLRP3 DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DE MALADIES INFECTIEUSES OU DU CANCER PAR ACTIVATION DE L'INFLAMMASOME NLRP3
  申请人：UNIV FREIBURG ALBERT LUDWIGS

  公开号：WO2022079246A1

  公开（公告）日：2022-04-21

  The present invention relates to a compound or pharmaceutically acceceptable salts thereof, that modulates NLRP3 in that the NLRP3 inflammasome is activated. This invention further relates to the compounds and/or compositions for use in the prevention and treatment of a condition, disease or a disorder by activating the NLRP3 inflammasome, wherein the disease is selected from a group comprising infectious diseases, or cancer. Moreover, the invention relates to the use of the present compounds for analyzing the activity of NLRP3 activation.

  本发明涉及一种化合物或其药学上可接受的盐，该化合物调节NLRP3，使NLRP3炎症小体被激活。本发明还涉及用于预防和治疗通过激活NLRP3炎症小体的疾病、疾病或障碍的化合物和/或组合物，其中该疾病选自感染性疾病或癌症等一组疾病。此外，本发明还涉及使用本化合物分析NLRP3激活的活性。
• NOVEL OXONOL DYE COMPOUND AND OPTICAL INFORMATION RECORDING MEDIUM
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP1759866A1

  公开（公告）日：2007-03-07

  An optical recording medium comprising a substrate having thereon a recording layer containing at least two kinds of dye A and dye B, wherein dye A and dye B satisfy the following conditions (1) and (2): (1) the starting temperature of decomposition is from 150 to 250°C, (2) refractive index n (A) and extinction coefficient k (A) of dye A at the wavelength of recording laser ray, and refractive index n (B) and extinction coefficient k (B) of dye B at the same wavelength satisfy the following expressions: nB/nA>0.7 kB/kA>10.

  一种光学记录介质，包括基底，基底上有记录层，记录层至少含有两种染料A和染料B，其中染料A和染料B满足以下条件(1)和(2)： (1) 分解的起始温度为 150 至 250°C、 (2) 染料 A 在记录激光波长处的折射率 n (A) 和消光系数 k (A)，以及染料 B 在相同波长处的折射率 n (B) 和消光系数 k (B) 满足以下表达式：nB/nA>0.7 kB/kA>10。
• Shape-memory resin performing remoldability and excellent in shape recovering property, and molded product composed of the cross-linked resin
  申请人：Shimura Midori

  公开号：US20070148465A1

  公开（公告）日：2007-06-28

  It is possible to provide a shape-memory molded product having excellent shape-memory properties and recycling efficiency by using a shape-memory resin having a glass transition temperature (Tg) within the range of 40° C. to 200° C. and a dissociation temperature (Td) of a thermo-reversible reaction within the range of 50° C. to 300° C. and satisfying the relationship: Tg+10° C.≦Td, wherein the resin is deformed at a temperature of Tg to less than Td, and cross-linked through a thermo-reversible reaction in which a covalent bond is formed by cooling and dissociated by heating.
• US7723460B2
  申请人：——

  公开号：US7723460B2

  公开（公告）日：2010-05-25