4-bromo-1-isopropylpyrazole-3-carbonitrile

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 4-bromo-1-isopropylpyrazole-3-carbonitrile
• 英文别名: 4-Bromo-1-isopropyl-1H-pyrazole-3-carbonitrile；4-bromo-1-propan-2-ylpyrazole-3-carbonitrile
• 化学式: C₇H₈BrN₃
• 分子量: 214.065
• InChiKey: BMLFJXONKLLQIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  41.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  异丙醇频哪醇硼酸酯 、 4-bromo-1-isopropylpyrazole-3-carbonitrile 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以62.9 %的产率得到3-cyano-1-isopropylpyrazol-4-ylboronic acid
  参考文献：
  名称：

  [EN] PYRROLOPYRIDONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER
  [FR] DÉRIVÉS DE PYRROLOPYRIDONE UTILES DANS LE TRAITEMENT DU CANCER

  摘要：

  This invention relates to compounds comprising a pyrrolopyridone core, and pharmaceutically-acceptable salts and compositions of such compounds. The compounds herein are useful as anti-inflammatory and/or other therapies.

  公开号：

  WO2023275542A1
• 作为产物：
  描述：

  4-溴-1H-吡唑-5-甲腈 、 2-溴丙烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 以54 %的产率得到4-bromo-1-isopropylpyrazole-3-carbonitrile
  参考文献：
  名称：

  [EN] PYRROLOPYRIDONE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER
  [FR] DÉRIVÉS DE PYRROLOPYRIDONE UTILES DANS LE TRAITEMENT DU CANCER

  摘要：

  This invention relates to compounds comprising a pyrrolopyridone core, and pharmaceutically-acceptable salts and compositions of such compounds. The compounds herein are useful as anti-inflammatory and/or other therapies.

  公开号：

  WO2023275542A1

文献信息

• COMPOUNDS FOR THE TREATMENT OF HIV
  申请人：Bondy Steven S.

  公开号：US20140142085A1

  公开（公告）日：2014-05-22

  The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.

  本发明提供了以下式子（I）的化合物或其盐，如本文所述。本发明还提供了包括式子（I）化合物的制药组合物，制备式子（I）化合物的方法，用于制备式子I化合物的中间体以及治疗逆转录病毒感染的治疗方法，包括由HIV病毒引起的感染。
• Pyrrolidine amide compounds as histone demethylase inhibitors
  申请人：GENENTECH, INC.

  公开号：US10022354B2

  公开（公告）日：2018-07-17

  The present invention relates to compounds useful as inhibitors of one or more histone demethylases, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.

  本发明涉及可用作一种或多种组蛋白去甲基化酶（如 KDM5）抑制剂的化合物。本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用所述组合物治疗各种疾病的方法。
• PYRROLIDINE AMIDE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS
  申请人：GENENTECH, INC.

  公开号：US20170312252A1

  公开（公告）日：2017-11-02

  The present invention relates to compounds useful as inhibitors of one or more histone demethylses, such as KDM5. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and methods of using said compositions in the treatment of various disorders.
• Compounds For the Treatment of HIV
  申请人：Gilead Sciences, Inc.

  公开号：US20180194746A1

  公开（公告）日：2018-07-12

  The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula I and therapeutic methods for treating a Retroviridae viral infection including an infection caused by the HIV virus.
• US9540343B2
  申请人：——

  公开号：US9540343B2

  公开（公告）日：2017-01-10