(2,5-Dioxopyrrolidin-1-yl) 5-oxo-5-(propan-2-ylamino)pentanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 5-oxo-5-(propan-2-ylamino)pentanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 5-oxo-5-(propan-2-ylamino)pentanoate
• 化学式: C₁₂H₁₈N₂O₅
• 分子量: 270.28
• InChiKey: DPXYHCZJXTUUTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  92.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ACTIVATED SIALIC ACID DERIVATIVES FOR PROTEIN DERIVATISATION AND CONJUGATION
  申请人：Lipoxen Technologies Limited

  公开号：EP3138855A1

  公开（公告）日：2017-03-08

  Derivatives of PSAs are synthesised, in which a reducing and/or nonreducing end terminal sialic acid unit is transformed into a N - hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.

  PSAs 衍生物的合成，是将还原性和/或非还原性末端硅酸单元转化为 N-羟基琥珀酰亚胺（NHS）基团。这些衍生物可与底物（例如含有胺或肼基团的底物）反应，形成非交联/交联多聚氨酰化合物。例如，底物可以是具有治疗作用的药物、肽或蛋白质或给药系统。
• Activated Sialic Acid Derivatives For Protein Derivatisation And Conjugation
  申请人：Lipoxen Technologies Limited

  公开号：US20140141486A1

  公开（公告）日：2014-05-22

  Derivatives of PSAs are synthesised, in which a reducing and/or non-reducing end terminal sialic acid unit is transformed into a N-hydroxysuccinimide (NHS) group. The derivatives may be reacted with substrates, for instance substrates containing amine or hydrazine groups, to form non-cross-linked/crosslinked polysialylated compounds. The substrates may, for instance, be therapeutically useful drugs, peptides or proteins or drug delivery systems.
• US8735557B2
  申请人：——

  公开号：US8735557B2

  公开（公告）日：2014-05-27
• US8952141B2
  申请人：——

  公开号：US8952141B2

  公开（公告）日：2015-02-10