1-Butyl-2-methyl-3-propyl-2,3-dihydropyrrole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 1-Butyl-2-methyl-3-propyl-2,3-dihydropyrrole
• 英文别名: 1-butyl-2-methyl-3-propyl-2,3-dihydropyrrole
• 化学式: C₁₂H₂₃N
• 分子量: 181.32
• InChiKey: ONYBLRGBWGYPOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] NOVEL GOLD(III) COMPLEXES CONTAINING N-HETEROCYCLIC CARBENE LIGAND, SYNTHESIS, AND THEIR APPLICATIONS IN CANCER TREATMENT AND THIOL DETECTION<br/>[FR] COMPLEXES À BASE D'OR(III) D'UN NOUVEAU TYPE CONTENANT UN LIGAND CARBÈNE N-HÉTÉROCYCLIQUE, SYNTHÈSE, ET LEURS APPLICATIONS DANS LE TRAITEMENT D'UN CANCER ET LA DÉTECTION DE THIOL
  申请人：UNIV HONG KONG

  公开号：WO2014075394A1

  公开（公告）日：2014-05-22

  Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growthin vivo.