(2E,5E)-2,5-bis[(5-methylfuran-2-yl)methylidene]cyclopentanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: (2E,5E)-2,5-bis[(5-methylfuran-2-yl)methylidene]cyclopentanone
• 英文别名: (2E,5E)-2,5-bis[(5-methylfuran-2-yl)methylidene]cyclopentan-1-one
• 化学式: C₁₇H₁₆O₃
• 分子量: 268.312
• InChiKey: QMFNMQZCEILUQX-UTLPMFLDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-甲基呋喃醛 、 环戊酮 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 12.0h， 以97%的产率得到(2E,5E)-2,5-bis[(5-methylfuran-2-yl)methylidene]cyclopentanone
  参考文献：
  名称：

  Sustainable production of biofuel precursors by aldol condensation with biomass-derived 5-methylfurfural

  摘要：

  DOI：

  10.1016/j.mencom.2022.05.037

文献信息

• ANTIBIOTIC COMPOUNDS THAT INHIBIT BACTERIAL PROTEIN SYNTHESIS
  申请人：The Board of Regents of the University of Texas System

  公开号：US20160220510A1

  公开（公告）日：2016-08-04

  An aminoacylation/translation (AIT) system based on the protein synthesis system from the pathogen Pseudomonas aeruginosa , was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: EF-Tu, EF-Ts and EF-G, aminoacyl tRNA synthetase (aaRS) specific for phenylalanine, PheRS, and ribosomes isolated from cultures of Pseudomonas aeruginosa . Compounds identified using this assay have been shown to contain broad spectrum activity against both Gram+ and Gram− pathogens. Methods of using the identified compounds, as well as derivatives and analogues of these compounds, as antimicrobial agents against bacterial infections are described.
• Sustainable production of biofuel precursors by aldol condensation with biomass-derived 5-methylfurfural
  作者：Konstantin I. Galkin

  DOI：10.1016/j.mencom.2022.05.037

  日期：2022.5