2-(Ethoxymethyl)-4-methylmorpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 2-(Ethoxymethyl)-4-methylmorpholine
• 英文别名: 2-(ethoxymethyl)-4-methylmorpholine
• 化学式: C₈H₁₇NO₂
• 分子量: 159.23
• InChiKey: PTLOKNSSAWBDPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] N-(ARYLALKYL)-N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS<br/>[FR] COMPOSÉS DE N-(ARYLALKYLE)-N'-PYRAZOLYLE-URÉE, DE THIOURÉE, DE GUANIDINE ET DE CYANOGUANIDINE EN TANT QU'INHIBITEURS DE LA KINASE TRKA
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2014078331A1

  公开（公告）日：2014-05-22

  Compounds of Formula I or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C, X, Ra, Rb, Rc, Rd and n are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

  公式I的化合物或立体异构体、互变异构体、或药用可接受的盐、溶剂化物或前药，其中环A、环C、X、Ra、Rb、Rc、Rd和n如本文所述定义，是TrkA激酶的抑制剂，可用于治疗可以用TrkA激酶抑制剂治疗的疾病，如疼痛、癌症、炎症/炎症性疾病、神经退行性疾病、某些传染病、舍格伦综合症、子宫内膜异位症、糖尿病周围神经病变、前列腺炎或骨盆疼痛综合征。
• [EN] N-(MONOCYCLIC ARYL),N'-PYRAZOLYL-UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS<br/>[FR] COMPOSÉS DE N-ARYLE MONOCYCLIQUES, N'-PYRAZOLYL-URÉE, THIOURÉE, GUANIDINE ET CYANOGUANIDINE UTILES COMME INHIBITEURS DE TRKA KINASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2014078325A1

  公开（公告）日：2014-05-22

  Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.

  化合物的公式(I)或其立体异构体、互变异构体、或其药学上可接受的盐、溶剂合物或前药，其中环A、环C和X如本文所定义，是TrkA激酶的抑制剂，并且在治疗可以用TrkA激酶抑制剂治疗的疾病中具有用处，如疼痛、癌症、炎症/炎症性疾病、神经退行性疾病、某些传染病、干燥综合征、子宫内膜异位症、糖尿病周围神经病变、前列腺炎或盆腔疼痛综合征。
• 1,7-DIAZACARBAZOLES AND METHODS OF USE
  申请人：Genentech, Inc.

  公开号：US20140171407A1

  公开（公告）日：2014-06-19

  The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

  该发明涉及化合物公式为(I)、(I-a)和(I-b)的1,7-二氮杂咔唑化合物，其作为激酶抑制剂具有用途，更具体地作为检查点激酶1（chk1）抑制剂，因此具有作为癌症治疗药物的用途。该发明还涉及包括这些化合物的组合物，更具体地是包括这些化合物的制药组合物以及使用它们治疗各种癌症和高增殖性疾病的方法，以及使用这些化合物进行哺乳动物细胞的体外、原位和体内诊断或治疗，或相关病理条件的方法。
• [EN] POLYMER COMPOSITIONS, FILMS, GELS, AND FOAMS CONTAINING SULFONYLIMIDE SALTS, AND ELECTRONIC DEVICES CONTAINING SUCH FILMS, GELS, AND FOAMS<br/>[FR] COMPOSITIONS, FILMS, GELS, ET MOUSSES POLYMÈRES CONTENANT DES SELS DE SULFONYLIMIDE, ET DISPOSITIFS ÉLECTRONIQUES CONTENANT LESDITS FILMS, GELS, ET MOUSSES
  申请人：RHODIA OPERATIONS

  公开号：WO2015088999A1

  公开（公告）日：2015-06-18

  Described herein are polymer films, polymer gels, and polymer foams each containing electrically conductive polymers and salts comprising sulfonylimide anions. The polymer films, polymer gels, and polymer foams are each useful as components of electronic devices.
• [EN] POLYMER FILMS, GELS, AND FOAMS CONTAINING ELECTRICALLY CONDUCTIVE PATTERNS, AND ELECTRONIC DEVICES CONTAINING SUCH FILMS, GELS, AND FOAMS<br/>[FR] FILMS, GELS ET MOUSSES POLYMÈRES CONTENANT DES MOTIFS ÉLECTRIQUEMENT CONDUCTEURS ET DISPOSITIFS ÉLECTRONIQUES CONTENANT CES FILMS, GELS ET MOUSSES
  申请人：RHODIA OPERATIONS

  公开号：WO2015089001A1

  公开（公告）日：2015-06-18

  Polymer films, polymer gels, and polymer foams each containing electrically conductive patterns comprising an ionic liquid, a salt comprising sulfonylimide anions, or a combination thereof. The polymer films, polymer gels, and polymer foams each containing electrically conductive patterns comprising an ionic liquid, a salt comprising sulfonylimide anions, or a combination thereof, are useful as components of electronic devices.