N-(5-methyl-6-oxoheptyl)-5-(1,2,3,4,6-pentahydroxyhexoxy)pentanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(5-methyl-6-oxoheptyl)-5-(1,2,3,4,6-pentahydroxyhexoxy)pentanamide
• 化学式: C₁₉H₃₇NO₈
• 分子量: 407.5
• InChiKey: OOWICLKMUXOYNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  157
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20150247143A1

  公开（公告）日：2015-09-03

  The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

  该发明涉及iRNA，例如双链核糖核酸（dsRNA），针对补体成分C5基因的组合物，以及使用这种iRNA，例如dsRNA，组合物来抑制C5的表达并治疗患有补体成分C5相关疾病的受试者，例如周期性夜间血红蛋白尿。
• Compositions and Methods for Inhibition of Expression of Protein C (PROC) Genes
  申请人：Toudjarska Ivanka

  公开号：US20140142162A1

  公开（公告）日：2014-05-22

  The invention relates to double-stranded ribonucleic acid (dsRNA) targeting a PROC gene, and methods of using the dsRNA to inhibit expression of PROC. At least one nucleotide of the dsRNA can be a modified nucleotide, e.g., a 2-0-methyl modified nucleotide, a nucleotide comprising a 5′-phosphorothioate group, and a terminal nucleotide linked to a cholesteryl derivative or dodecanoic acid bisdecylamide group. Other examples of modified nucleotides include a 2′-deoxy-2′-fluoro modified nucleotide, a 2′-deoxymodified nucleotide, a locked nucleotide, an abasic nucleotide, 2′-amino-modified nucleotide, 2′-alkyl-modified nucleotide, morpholino nucleotide, a phosphoramidate, and a non-natural base comprising nucleotide. A dsRNA of the invention can include one or more of any of these modified nucleotides.
• Compositions and methods for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression
  申请人：Alnylam Pharmaceuticals, Inc.

  公开号：US20160186172A1

  公开（公告）日：2016-06-30

  The invention relates to lipid formulated double-stranded ribonucleic acid (dsRNA) targeting a hepcidin antimicrobial peptide (HAMP) and/or HAMP-related gene, and methods of using the dsRNA to inhibit expression of HAMP and/or HAMP-related genes.
• US9249415B2
  申请人：——

  公开号：US9249415B2

  公开（公告）日：2016-02-02