2-butyl-1,3-propanediamine | 88989-21-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-butyl-1,3-propanediamine
• 英文别名: 2-Butylpropane-1,3-diamine
• CAS: 88989-21-3
• 化学式: C₇H₁₈N₂
• mdl: MFCD19207184
• 分子量: 130.233
• InChiKey: BPCDZYHKSMRSLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-butyl-1,3-propanediamine 在 吡啶 、 碘 、 potassium carbonate 、 sodium hydroxide 作用下， 以 二氯甲烷 、 二甲基亚砜 、 叔丁醇 为溶剂， 反应 6.0h， 生成 2-(3,4-methylenedioxyphenyl)-5-(n-butyl)pyrimidine
  参考文献：
  名称：

  Efficient and Benign One-Pot Conversion of N-Tosyl-1,4,5,6-tetrahydropyrimidines to Pyrimidines via Tandem β-Elimination and Aromatization

  摘要：

  An efficient, mild, benign, and practical method for one-pot conversion of N-tosyl-1,4,5,6-tetrahydropyrimidines into pyrimidines is discussed in detail. In this method, N-tosyl-1,4,5,6-tetrahydropyrimidines are first prepared via N-tosylation of tetrahydropyrimidines with TsCl and then treated with 1.5 equivalents of NaOH in dimethylsulfoxide (DMSO) under air at 60 degrees C to afford corresponding pyrimidines in 70-95% yields via cascade -elimination and aromatization. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resources: Full experimental and spectral details.]

  DOI：

  10.1080/00397911.2013.764433
• 作为产物：
  描述：

  2-丁基-1,3-丙二醇 在 lithium aluminium tetrahydride 、 sodium azide 作用下， 以 四氢呋喃 、 吡啶 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 2-butyl-1,3-propanediamine
  参考文献：
  名称：

  Lipophilic complexones, part 3. Synthesis of polyamines derived from 2-alkyl-1,3-propanediols and 2,2-bis(hydroxymethyl)alkanols

  摘要：

  DOI：

  10.1007/bf00799031

文献信息

• Nicotinic acetylcholine receptor binding of imidacloprid-related diaza compounds with various ring sizes and their insecticidal activity againstMusca domestica
  作者：Shinzo Kagabu、Hisashi Nishiwaki、Kazuyuki Sato、Manabu Hibi、Nahato Yamaoka、Yoshiaki Nakagawa

  DOI：10.1002/ps.488

  日期：2002.5

  related compounds having a five- or seven-membered ring were synthesized and their biological activities were measured in vivo and in vitro. The insecticidal (in vivo) activity was evaluated against houseflies Musca domestica L under synergistic conditions with propargyl propyl phenyl phosphonate and piperonyl butoxide. The binding activity of each compound to nicotinic acetylcholine receptor in vitro

  合成了十五个5-取代的1-（6-氯-3-吡啶基甲基）-2-硝基亚甲基-1,3-二氮杂环己烷和其他三个具有五或七元环的相关化合物，并在体内和体外测量了它们的生物学活性。体外。在炔丙基丙基苯基膦酸酯和胡椒基丁醇的协同条件下，评价了对家蝇Musca家蝇L的杀虫（体内）活性。使用[125I]α-真菌毒素测量了每种化合物在体外对烟碱乙酰胆碱受体的结合活性。未取代的二氮杂环己烷类似物的杀虫活性略高于咪唑烷类似物，但环大小扩大到二氮杂环庚烷降低了杀虫活性。替代1 3-二氮杂环己烷或咪唑烷环通常对该活性不利，但是未取代的1，3-二氮杂环己烷类似物显示出最高的结合活性。环取代和环扩大使活性降低了100-30,000倍。
• LIQUID-CRYSTALLINE MEDIA HAVING HOMEOTROPIC ALIGNMENT
  申请人：Merck Patent GmbH

  公开号：US20150252265A1

  公开（公告）日：2015-09-10

  The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy, comprising a low-molecular-weight component and a polymerizable component. The polymerizable component comprises self-aligning, polymerizable mesogens (polymerizable self-alignment additives) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the LC medium without alignment layers. The invention discloses novel structures for self-alignment additives which have a certain position of the functional groups.

  本发明涉及具有正或负介电各向异性的液晶介质（LC介质），包括低分子量成分和可聚合成分。可聚合成分包括自排列、可聚合的介质基（可聚合自排列添加剂），可在液晶显示器（LC显示器）的表面或细胞壁处实现LC介质的同向（垂直）排列。因此，本发明还包括具有同向排列的LC介质的LC显示器，而无需排列层。本发明还揭示了自排列添加剂的新结构，其具有某些功能基团的位置。
• [EN] DYE COMPOUND, INK, AND RESIST COMPOSITION FOR COLOR FILTER<br/>[FR] COMPOSÉ COLORANT, ENCRE, ET COMPOSITION D'AGENT DE RÉSERVE POUR FILTRE COLORÉ
  申请人：CANON KK

  公开号：WO2015046618A1

  公开（公告）日：2015-04-02

  The present invention provides a dye compound excellent in both chroma and light fastness, an ink, and a resist composition for a color filter. The present invention provides an ink and a resist composition for a color filter, in which each of the ink and the resist composition contains a pyridone azo compound having a specific structure.

  本发明提供了一种染料化合物，其色度和耐光性均优异，以及一种油墨和用于彩色滤光片的抗蚀剂组合物。本发明提供了一种油墨和用于彩色滤光片的抗蚀剂组合物，其中油墨和抗蚀剂组合物中各含有一种具有特定结构的吡啶酮偶氮化合物。
• NOVEL PLATINUM (II) COMPLEX AND REMEDY FOR MALIGNANT TUMOR
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0704453A1

  公开（公告）日：1996-04-03

  A novel platinum complex (II) represented by general formula (A) and a remedy for malignant tumor containing the same as the active ingredient, wherein R₁ represents a C₁-C₃ lower hydrocarbon group; R₂ ad R₃ represent each independently hydrogen or a C₁-C₃ lower hydrocarbon group, or R₂ and R₃ may be combined together to represent -(CH₂)₄- or -(CH₂)₅-; Y and Z represent each independently ammonia or a monodentate amine having a C₁-C₇ hydrocarbon group, or Y and Z may be combined together to represent a didentate diamine having a C₂-C₁₀ hydrocarbon group; and X- represents an inorganic acid anion or an organic carboxylic acid anion. This compound is efficacious against cisplatin-resistant cancer, has a solubility suitable for intravenous administration, is stable in aqueous solution, and has an excellent antitumor activity.

  一种由通式(A)表示的新型铂络合物(II)和一种治疗恶性肿瘤的药物，其中 R₁ 代表 C₁-C₃低级烃基；R₂ 和 R₃ 各自独立地代表氢或 C₁-C₃低级烃基，或 R₂ 和 R₃ 可结合在一起代表-(CH₂)₄- 或-(CH₂)₅-；Y 和 Z 各自独立地代表氨或具有 C₁-C₇烃基的单阳离子胺，或者 Y 和 Z 组合在一起代表具有 C₂-C₁₀ 烃基的双阳离子二胺；以及 X- 代表无机酸阴离子或有机羧酸阴离子。该化合物对顺铂抗性癌症有效，溶解度适合静脉注射，在水溶液中稳定，具有极佳的抗肿瘤活性。
• Liquid crystalline media having homeotropic alignment
  申请人：MERCK PATENT GMBH

  公开号：US10294426B2

  公开（公告）日：2019-05-21

  The present invention relates to liquid-crystalline media (LC media) having negative or positive dielectric anisotropy, comprising a low-molecular-weight component and a polymerizable component. The polymerizable component comprises self-aligning, polymerizable mesogens (polymerizable self-alignment additives) which effect homeotropic (vertical) alignment of the LC media at a surface or the cell walls of a liquid-crystal display (LC display). The invention therefore also encompasses LC displays having homeotropic alignment of the LC medium without alignment layers. The invention discloses novel structures for polymerizable self-alignment additives which have a certain position of the functional groups.

  本发明涉及具有负或正介电常数各向异性的液晶介质，包括低分子量组分和可聚合组分。可聚合成分包括可聚合的自对准中间体（可聚合的自对准添加剂），可使液晶介质在液晶显示器（LC 显示器）的表面或单元壁上实现各向同性（垂直）对准。因此，本发明也包括液晶显示屏，其液晶介质具有各向同性对准功能，无需对准层。本发明公开了可聚合自对准添加剂的新型结构，其官能团具有一定的位置。