2-benzyl-1-(4-methoxyphenyl)-3,5-diphenyl-1H-pyrrole | 1126271-20-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2-benzyl-1-(4-methoxyphenyl)-3,5-diphenyl-1H-pyrrole
• 英文别名: 2-Benzyl-1-(4-methoxyphenyl)-3,5-diphenylpyrrole；2-benzyl-1-(4-methoxyphenyl)-3,5-diphenylpyrrole
• CAS: 1126271-20-2
• 化学式: C₃₀H₂₅NO
• 分子量: 415.535
• InChiKey: DRUGDUMQTDTGHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  14.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (Z)-1,3,5-triphenylpent-2-en-4-ynyl acetate 、 甲氧苯胺 在 potassium chloride 、 palladium dichloride 作用下， 以 水 、 乙腈 为溶剂， 反应 12.0h， 以82%的产率得到2-benzyl-1-(4-methoxyphenyl)-3,5-diphenyl-1H-pyrrole
  参考文献：
  名称：

  Efficient synthesis of highly substituted pyrroles based on the tandem reactions: intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation

  摘要：

  A novel and efficient method for construction of polysubstituted pyrroles, which included an intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation, was developed. It was found that the reactions gave high yields (55-92%). Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.12.018

文献信息

• Efficient synthesis of highly substituted pyrroles based on the tandem reactions: intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation
  作者：Yong-Jiang Bian、Xue-Yuan Liu、Ke-Gong Ji、Xing-Zhong Shu、Li-Na Guo、Yong-Min Liang

  DOI：10.1016/j.tet.2008.12.018

  日期：2009.2

  A novel and efficient method for construction of polysubstituted pyrroles, which included an intermolecular amination and Pd(II)-catalyzed intramolecular hydroamidation, was developed. It was found that the reactions gave high yields (55-92%). Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.