Benzyl 5-methyl-5-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethylamino]-4-oxo-3-(propan-2-ylamino)heptanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Benzyl 5-methyl-5-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethylamino]-4-oxo-3-(propan-2-ylamino)heptanoate
• 英文别名: benzyl 5-methyl-5-[2-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]ethylamino]-4-oxo-3-(propan-2-ylamino)heptanoate
• 化学式: C₂₉H₄₉N₃O₇
• 分子量: 551.7
• InChiKey: UTYWWZXHKCVPDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  39
• 可旋转键数：
  22
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• [EN] MULTI-ARM BIODEGRADABLE POLYMERS FOR NUCLEIC ACID DELIVERY<br/>[FR] POLYMÈRES BIODÉGRADABLES MULTI-BRAS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：BAYLOR COLLEGE MEDICINE

  公开号：WO2014078399A1

  公开（公告）日：2014-05-22

  In some embodiments, the present disclosure pertains to compositions for nucleic acid delivery into cells. In some embodiments, the composition comprises: (1) a cationic polymer unit comprising a plurality of polymeric arms, where the plurality of polymeric arms comprise poly(aspartic acid) derivatives; and (2) a nucleic acid associated with the cationic polymer unit. In some embodiments, the cationic polymer unit comprises a linker covalently associated with the plurality of polymeric arms. In some embodiments, the cationic polymer unit has a dendritic shape. In some embodiments, the cationic polymer unit has a star-like shape. In some embodiments, the cationic polymer unit is biodegradable. Further embodiments of the present disclosure pertain to methods of delivering a nucleic acid into cells by introducing into the cells one or more of the compositions of the present disclosure.