[(Z)-octadec-9-enyl] (2S)-2-amino-3-(4-hydroxyphenyl)propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(Z)-octadec-9-enyl] (2S)-2-amino-3-(4-hydroxyphenyl)propanoate
• 化学式: C₂₇H₄₅NO₃
• 分子量: 431.7
• InChiKey: RCVNCXQQGIPYBN-IMHHWWNFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  31
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  72.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Pro-pigmenting peptides
  申请人：Sederma

  公开号：US10231917B2

  公开（公告）日：2019-03-19

  The invention is directed to the use of at least one peptide of formula: X—(Xaa1)n-Pro*-(Xaa2)m-Y (I) With: —n=0, 1 or 2; —m=0 or 1 and if m=0 then n≠0-Xaai is: —An hydrophobic amino acid; —A polar amino acid; —or Glycine (Gly, G); When n=2 the two amino acids Xaa1 can be the same or different; —Xaa2 is: —An hydrophobic amino acid; —A basic amino acid Glycine (Gly, G) or Serine (Ser, S); —At the N terminal end of the peptide, X is selected from H, —CO—R1 and —SO2—R1; —At the C terminal end of the peptide, Y is selected from OH, OR1, NH2, NHR1 or NR1R2, R1 and R2 being independently from each other, selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy and aryloxy group; Excluding the peptides where X=H and Y=OH, for a non therapeutical cosmetic pro-pigmenting treatment of skin.

  本发明涉及至少一种式肽的用途：X-(Xaa1)n-Pro*-(Xaa2)m-Y(I) 式中：-n=0、1或2；-m=0或1，如果m=0，则n≠0-Xaai是：-一种疏水性氨基酸；-一种极性氨基酸；-或甘氨酸（Gly，G）；当n=2时，两种氨基酸Xaa1可以相同或不同；-Xaa2是：-一种疏水性氨基酸；-一种碱性氨基酸甘氨酸（Gly，G）或丝氨酸（Ser，S）：-在肽的 N 端，X 选自 H、-CO-R1 和-SO2-R1；-在肽的 C 端，Y 选自 OH、OR1、NH2、NHR1 或 NR1R2，R1 和 R2 相互独立，选自烷基、芳基、芳烷基、烷芳基、烷氧基和芳氧基。
• PRO-PIGMENTING PEPTIDES
  申请人：Sederma

  公开号：EP2922864A2

  公开（公告）日：2015-09-30
• Pro-Pigmenting Peptides
  申请人：Sederma

  公开号：US20200253852A1

  公开（公告）日：2020-08-13

  The invention is directed to the use of at least one peptide of formula: X-(Xaa 1 ) n -Pro*-(Xaa 2 ) m -Y (I) With: -n=0, 1 or 2; -m=0 or 1 and if m=0 then n≠0 -Xaa 1 is: -An hydrophobic aminoacid selected from Alanine (Ala, A), Valine (Val, V), Methionine (Met, M), Leucine (Leu, L), Isoleucine (Ile, I), Phenylalanine (Phe, F), Proline (Pro, P) and analogues and derivatives thereof; -A polar aminoacid selected from Serine (Ser, S), Threonine (Thr, T), Tyrosine (Tyr, Y), Asparagine (Asn, N), Glutamine (Gln, Q) and analogues and derivatives thereof; -or Glycine (Gly, G); When n=2 the two aminoacids Xaa 1 can be the same or different; -Xaa 2 is: -An hydrophobic aminoacid selected from Alanine (Ala, A), Valine (Val, V), Methionine (Met, M), Leucine (Leu, L), Isoleucine (Ile, I), Phenylalanine (Phe, F), Proline (Pro, P) and analogues and derivatives thereof; -A basic aminoacid selected from Arginine (Arg, R), Lysine (Lys, K) and Histidine (His, H) and analogues and derivatives thereof; -Glycine (Gly, G) or Serine (Ser, S); -At the N terminal end of the peptide, X is selected from H, —CO—R 1 and —SO 2 —R 1 ; -At the C terminal end of the peptide, Y is selected from OH, OR 1 , NH 2 , NHR 1 or NR 1 R 2 , R 1 and R 2 being independently from each other, selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy and aryloxy group, that can be linear, branched, cyclic, poly-cyclic, non-saturated, hydroxylated, carbonylated, phosphorylated and/or sulphured, with the possibility to have in said group skeleton a O, S and/or N heteroatom; -Pro* corresponding to a Proline, an analogue or derivative thereof; Excluding the peptides where X=H and Y=OH, for a non therapeutical cosmetic pro-pigmenting treatment of skin. The invention also encompasses new tripeptides of formula (I) suitable for a non therapeutical cosmetic treatment of skin.
• US9534015B2
  申请人：——

  公开号：US9534015B2

  公开（公告）日：2017-01-03
• [EN] PRO-PIGMENTING PEPTIDES<br/>[FR] PEPTIDES PRO-PIGMENTANTS
  申请人：SEDERMA SA

  公开号：WO2014080376A2

  公开（公告）日：2014-05-30

  The invention is directed to the use of at least one peptide of formula: X –(Xaa1 ) n –Pro* –(Xaa2)m –Y (I) With: -n = 0, 1 or 2; -m =0 or 1and if m = 0 then n ≠ 0 -Xaa is: -An hydrophobic aminoacid selected from Alanine (Ala, A), Valine (Val, V), Methionine (Met, M), Leucine (Leu, L), Isoleucine (Ile, I), Phenylalanine (Phe, F), Proline (Pro, P) and analogues and derivatives thereof; -A polar aminoacid selected from Serine (Ser, S), Threonine (Thr, T), Tyrosine (Tyr, Y), Asparagine (Asn, N), Glutamine (Gln, Q)and analogues and derivatives thereof; or -Glycine (Gly, G); When n = 2 the two aminoacids Xaa1 can be the same or different; -Xaa2 is: -An hydrophobic aminoacid selected from Alanine (Ala, A), Valine (Val, V), Methionine (Met, M), Leucine (Leu, L), Isoleucine (Ile, I), Phenylalanine (Phe, F), Proline (Pro, P) and analogues and derivatives thereof; -A basic aminoacid selected from Arginine (Arg, R), Lysine (Lys, K) and Histidine (His, H) and analogues and derivatives thereof; -Glycine (Gly, G) or Serine (Ser, S); -At the N terminal end of the peptide, X is selected from H, -CO-R1 and -SO2 -R1; -At the C terminal end of the peptide, Y is selected from OH, OR1, NH2, NHR1 or NR1 R2, -R1 and R2 being independantly from each other, selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy and aryloxy group, that can be linear, branched, cyclic, poly-cyclic, non- saturated, hydroxylated, carbonylated, phosphorylated and/or sulphured, with the possibility to have in said group skeleton a O, S and/or N heteroatom; -Pro* corresponding to a Proline, an analogue or derivative thereof; Excluding the peptides where X=H and Y=OH, for a non therapeutical cosmetic pro-pigmenting treatment of skin. The invention also encompasses new tripeptides of formula (I) suitable for a non therapeutical cosmetic treatment of skin.