[(6S,7R,8R)-8-benzyl-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-[(3-hydroxy-4-methoxypyridine-2-carbonyl)amino]-2-methylpropanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(6S,7R,8R)-8-benzyl-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-[(3-hydroxy-4-methoxypyridine-2-carbonyl)amino]-2-methylpropanoate
• 化学式: C₂₆H₃₀N₂O₉
• 分子量: 514.5
• InChiKey: MIJXGGNPRACTGN-JZJGZRSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Antimicrobial Peptides and Methods of Use
  申请人：Hodges Robert S.

  公开号：US20130035469A1

  公开（公告）日：2013-02-07

  Disclosed herein are novel antimicrobial peptides with useful, improved, or superior properties such as antimicrobial activity, specificity, resistance to degradation desirable levels of hemolytic activity, and therapeutic index against a broad range of microorganisms including gram-negative and gram-positive bacteria and other organisms having a cellular or structural component of a lipid bilayer membrane. Also provided are methods of making and using such peptides to control microbial growth and in pharmaceutical compositions for treatment or prevention of infections caused by such microorganisms. Certain peptides result from structure-based rational design relating to antimicrobial peptide V681, with single D-/L-amino acid substitutions or charged residue substitutions in or near the center of the peptide on the nonpolar or polar face. Some peptides contain one or more (or all) amino acids in the D configuration. Compositions disclosed herein have useful clinical potential as antibiotics including broad spectrum antibiotics.
• N-ACYLIMINO HETEROCYCLIC COMPOUNDS
  申请人：BASF SE

  公开号：US20160297793A1

  公开（公告）日：2016-10-13

  The present invention relates to N-acylimino compound of formula (I): wherein X is O or S, in particular O; Y is a single bond, O, S or NR 5 ; Het is a 5 or 6 membered carbon-bound or nitrogen-bound heterocyclic ring, W 1 —W 2 —W 3 —W 4 represents a carbon chain group connected to N and C═N, and thus forming a saturated, unsaturated, or partially unsaturated 5 or 6 membered nitrogen containing heterocycle, wherein W 1 , W 2 , W 3 and W 4 each individually represent CR v R w ; R 1 , R 2 may be hydrogen, halogen, etc.; R 3 may be hydrogen, CN, C 1 -C 6 -alkyl, etc.; R 4 may be of hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkinyl, C 3 -C 8 -cycloalkyl, Q-phenyl, Q′-O-phenyl, Q′-S-phenyl, where the phenyl ring is optionally substituted with one or more, e.g. 1, 2, 3, 4 or 5 identical or different substituents R 10 , and the moieties Q-Het # , Q′-O-Het # and Q′-S-Het # where Het# represents a heterocyclic radical and where Q and Q′ are C1-C6-alkandiyl, C2-C6-alkendiyl, or C2-C6-alkyndiyl, and where Q may also be a single bond; R 3 and R 4 together may also may also a bivalent radical, selected from the group consisting of C 2 -C 5 -alkandiyl, C 2 -C 5 -alkendiyl, Q″-C 1 -C 4 -alkandiyl and Q″-C 2 -C 4 -alkendiyl, where Q″ is O or S. The invention also relates to the use of the N-acylimino heterocyclic compounds, their stereoisomers, their tautomers and their salts, for combating invertebrate pests. Furthermore the invention relates also to methods of combating invertebrate pests, which comprises applying such compounds.
• US9783523B2
  申请人：——

  公开号：US9783523B2

  公开（公告）日：2017-10-10
• [EN] PESTICIDAL MIXTURES<br/>[FR] MÉLANGES PESTICIDES
  申请人：BASF SE

  公开号：WO2014079804A1

  公开（公告）日：2014-05-30

  The present invention relates to pesticidal mixtures comprising one biological compound and at least one fungicidal, insecticidal or plant growth regulating compound and respective agricultural uses thereof as defined herein.