4-[5-(3-Methylphenoxy)pentyl]morpholine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[5-(3-Methylphenoxy)pentyl]morpholine
• 化学式: C₁₆H₂₅NO₂
• 分子量: 263.37
• InChiKey: FUGRMCXXHCFXEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• METHODS OF TREATING LEUKODYSTROPHIES
  申请人：Ramot at Tel-Aviv University Ltd.

  公开号：EP3634422A1

  公开（公告）日：2020-04-15
• US8372971B2
  申请人：——

  公开号：US8372971B2

  公开（公告）日：2013-02-12
• [EN] METHODS OF TREATING LEUKODYSTROPHIES<br/>[FR] MÉTHODES DE TRAITEMENT DE LA LEUCODYSTROPHIE
  申请人：UNIV RAMOT

  公开号：WO2018207192A1

  公开（公告）日：2018-11-15

  Methods of treating leukodystrophy are provided. Accordingly there is provided a method of treating leukodystrophy in a subject, the method comprising administering to the subject a therapeutically effective amount of an agent capable of up-regulating activity and/or expression of a component participating in a Sigma-1 Receptor (Sig-1R) signaling pathway. Also provided are agents and methods of up-regulating activity of Sig-1R in a cell and treating a disease that can benefit from up-regulating activity of Sig-1R. Also provided are agents and methods of modulating activity of sonic hedgehog (SHH) in a cell and treating a disease that can benefit from modulating activity of SHH.