N-methyl-N-[(3,4,5-trimethoxyphenyl)methyl]propanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-methyl-N-[(3,4,5-trimethoxyphenyl)methyl]propanamide
• 化学式: C₁₄H₂₁NO₄
• 分子量: 267.32
• InChiKey: YIZWXEZGOIONKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Emetine Derivatives, Prodrugs Containing Same, And Methods Of Treating Conditions Using Same
  申请人：Bakare Oladapo

  公开号：US20140148377A1

  公开（公告）日：2014-05-29

  Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2′-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.
• US9492560B2
  申请人：——

  公开号：US9492560B2

  公开（公告）日：2016-11-15