N-(5-methyl-6-oxoheptyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(5-methyl-6-oxoheptyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexanamide
• 化学式: C₂₀H₃₇NO₈
• 分子量: 419.5
• InChiKey: AACHWCAPZFCMJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  29
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  146
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF CD274/PD-L1 GENE
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20140148497A1

  公开（公告）日：2014-05-29

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the CD274/PD-L1 gene, and methods of using such dsRNA compositions to inhibit expression of CD274/PD-L1.
• COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE
  申请人：ALNYLAM PHARMACEUTICALS, INC.

  公开号：US20150111841A1

  公开（公告）日：2015-04-23

  The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the ALAS1 gene, and methods of using such dsRNA compositions to alter (e.g., inhibit) expression of ALAS1.