N-(cyclopropylmethyl)-N-pentylmethanesulfonamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: N-(cyclopropylmethyl)-N-pentylmethanesulfonamide
• 化学式: C₁₀H₂₁NO₂S
• 分子量: 219.35
• InChiKey: MVLMKAYLPQMCGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Autophagy Inhibitors
  申请人：MacKeigan Jeffrey Paul

  公开号：US20140148451A1

  公开（公告）日：2014-05-29

  The present invention relates to compounds of formulas III and V that are useful as pharmaceutical agents, particularly as autophagy inhibitors.

  本发明涉及公式III和V的化合物，这些化合物可用作药物制剂，特别是作为自噬抑制剂。
• US9221760B2
  申请人：——

  公开号：US9221760B2

  公开（公告）日：2015-12-29
• [EN] AUTOPHAGY INHIBITORS<br/>[FR] INHIBITEURS D'AUTOPHAGIE
  申请人：VAN ANDEL RES INST

  公开号：WO2015085229A1

  公开（公告）日：2015-06-11

  The present invention relates to compounds of Formula III, Formula 111(a), Formula V, Formula V(a), Formula A, Formula A 1, Formula A2, Formula A 3, or a pharmaceutically acceptable salt thereof that are useful as pharmaceutical agents, individually and/or in a combination with a chemotherapeutic agent: PLX-4032 (vemurafenib), or the catalytic mTOR inhibitor AZD8055, to treat a cancer and/or a cancer metastasis, for example a cancer harboring a BRAF protein kinase mutation and/or a HRAS protein mutation. Also, a method of treating and/or preventing malaria in a subject, the method comprising administering a therapeutically effective amount of a compound of Formula A, Formula A 1, Formula A2, Formula A 3, or a pharmaceutically acceptable salt thereof to the subject in need.