(2E,4Z,5E)-2-cyano-N,N-diethyl-7-hydroxy-4-(2-hydroxyethylidene)-6-nitrohepta-2,5-dienamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2E,4Z,5E)-2-cyano-N,N-diethyl-7-hydroxy-4-(2-hydroxyethylidene)-6-nitrohepta-2,5-dienamide
• 化学式: C14H19N3O5
• 分子量: 309.32
• InChiKey: BBWFBXLOTLTTOV-QEPMFCNYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  130
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Entacapone for prevention and treatment of obesity and related metabolic diseases
  申请人：NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING

  公开号：US20140148383A1

  公开（公告）日：2014-05-29

  Obesity is inhibited by administering to a person in need thereof an effective amount of entacapone ((2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide), or a pharmaceutically-acceptable salt thereof, particularly in conjunction with a second, different anti-obesity medicament. Pharmaceutical compositions comprise entacapone copackaged or coformulated with a second, different anti-obesity medicament.