(2S)-5-amino-2-[methyl(octanoyl)amino]-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-5-amino-2-[methyl(octanoyl)amino]-5-oxopentanoic acid
• 化学式: C₁₄H₂₆N₂O₄
• 分子量: 286.37
• InChiKey: NOGXDBQPVQUNNQ-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  20
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  101
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Drug-coated balloon catheters for body lumens
  申请人：Urotronic, Inc.

  公开号：US10806830B2

  公开（公告）日：2020-10-20

  Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

  所公开的各种实施方案涉及用于治疗体腔狭窄的药物涂层球囊导管及其使用方法。一种用于向体腔狭窄的目标部位输送治疗剂的药物涂层球囊导管包括一个具有主直径的细长球囊。球囊导管包括覆盖在球囊外表面的涂层。涂层包括一种或多种水溶性添加剂和治疗剂的初始药物负荷。
• Balloon catheters for body lumens
  申请人：Urotronic, Inc.

  公开号：US10850076B2

  公开（公告）日：2020-12-01

  Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

  所公开的各种实施方案涉及用于治疗体腔狭窄的药物涂层球囊导管及其使用方法。一种用于向体腔狭窄的目标部位输送治疗剂的药物涂层球囊导管包括一个具有主直径的细长球囊。球囊导管包括覆盖在球囊外表面的涂层。涂层包括一种或多种水溶性添加剂和治疗剂的初始药物负荷。
• Drug coated balloon catheters for nonvascular strictures
  申请人：Urotronic, Inc.

  公开号：US10888640B2

  公开（公告）日：2021-01-12

  Embodiments of the present invention provide a method of treating a stricture in a nonvascular body lumen such as urethral strictures, benign prostatic hyperplasia (BPH) strictures, ureteral strictures, esophageal strictures, sinus strictures, and biliary tract strictures. Embodiments of the present invention provide a method for treating at least one of benign prostatic hyperplasia (BPH), prostate cancer, asthma, and chronic obstructive pulmonary disease (COPD). The method can include delivering, for example, via drug coated balloon catheters, anti-inflammatory and anti-proliferative drugs (e.g., rapamycin, paclitaxel, and their analogues) and one or more additives.

  本发明的实施方案提供了一种治疗非血管性体腔狭窄的方法，例如尿道狭窄、良性前列腺增生（BPH）狭窄、输尿管狭窄、食管狭窄、窦道狭窄和胆道狭窄。 本发明的实施方案提供了一种治疗良性前列腺增生症（BPH）、前列腺癌、哮喘和慢性阻塞性肺病（COPD）中至少一种疾病的方法。 该方法可包括例如通过药物涂层球囊导管输送抗炎和抗增生药物（如雷帕霉素、紫杉醇及其类似物）以及一种或多种添加剂。
• METHOD FOR EVALUATING BACTERIAL CELL WALL INTEGRITY
  申请人：Universidad Autónoma de Madrid

  公开号：EP2738262B1

  公开（公告）日：2022-02-09
• DRUG COATED BALLOON CATHETERS FOR NONVASCULAR STRICTURES
  申请人：Urotronic, Inc.

  公开号：EP3285820A1

  公开（公告）日：2018-02-28