L-Norvalyl-norvalin | 58910-51-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Norvalyl-norvalin
• 英文别名: 2-(2-Amino-pentanoylamino)-pentanoic acid；2-[[(2S)-2-aminopentanoyl]amino]pentanoic acid
• CAS: 58910-51-3；65849-99-2；113395-49-6；114148-89-9
• 化学式: C₁₀H₂₀N₂O₃
• 分子量: 216.28
• InChiKey: GXIUBDXQTKVCGU-JAMMHHFISA-N

物化性质

• 熔点：
  270 °C (decomp)
• 沸点：
  426.1±30.0 °C(Predicted)
• 密度：
  1.089±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Pharmaceutical compounds
  申请人：Cuthbertson Alan

  公开号：US20070134155A1

  公开（公告）日：2007-06-14

  The invention comprises pharmaceuticals of formula (I) Z-(L) n -V, wherein V denotes a peptide, L denotes an optional linker, Z denotes a group that optionally can carry an imaging moiety M, n denotes 0 or 1. The pharmaceuticals are active as therapeutic agents for the treatment of heart failure, cardiac arrhythmias and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis and are also useful as diagnostic agents for the diagnosis of heart failure and diseases were fibrosis is prominent such as COPD, liver fibrosis and atherosclerosis.
• Pharmaceutical Compounds
  申请人：Lovhaug Dagfinn

  公开号：US20070297979A1

  公开（公告）日：2007-12-27

  A pharmaceutical of the general formula Z-(L) n -V, wherein V denotes an amino acid sequence X 1 —X 2 -Val-Tyr-Ile-His-Pro-X 8 —X 9 —X 10 ; L denotes a bond or a linker; Z denotes a group that optionally can carry an imaging moiety M; X 1 denotes an amino acid; X 2 denotes Arg or N-alkylated Arg or a mimetic of Arg ; X 8 , X 9 and X 10 constitute an ACE cleavage site; Z forms a bond with the amino acid X 1 optionally through the linker L; and M where denotes an imageable moiety capable of detection either directly or indirectly in a diagnostic imaging procedure.
• US7763234B2
  申请人：——

  公开号：US7763234B2

  公开（公告）日：2010-07-27
• US7785566B2
  申请人：——

  公开号：US7785566B2

  公开（公告）日：2010-08-31