(NZ)-N-[2-(N-[(2Z)-2-hydroxyimino-2-phenylethyl]-4-methoxyanilino)-1-phenylethylidene]hydroxylamine | 248583-85-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (NZ)-N-[2-(N-[(2Z)-2-hydroxyimino-2-phenylethyl]-4-methoxyanilino)-1-phenylethylidene]hydroxylamine
• CAS: 248583-85-9
• 化学式: C₂₃H₂₃N₃O₃
• 分子量: 389.454
• InChiKey: NDDVXRBYZXGOJO-BQASJOSNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  77.6
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (NZ)-N-[2-(N-[(2Z)-2-hydroxyimino-2-phenylethyl]-4-methoxyanilino)-1-phenylethylidene]hydroxylamine 在 异氰酸苯酯 作用下， 以 乙腈 为溶剂， 反应 2.5h， 以50%的产率得到5-(4-methoxy-phenyl)-3-phenyl-5,6-dihydro-4H-[1,2,5]oxadiazine
  参考文献：
  名称：

  Beckmann Fragmentation of Diphenylcarbamoylated N-Aryldiphenacylamine Dioximes. New Method for the Synthesis of Imidazooxadiazolones

  摘要：

  N-Aryl-N,N-diphenacylamine dioximes were prepared by the reaction of corresponding arylamines with alpha-bromoacetophenone oxime in ethanol-water at room temperature. These compounds reacted with aryl isocyanates in acetonitrile to give imidazooxadiazolones 9. The probable mechanism of the reaction is discussed.

  DOI：

  10.1080/00397919908085909
• 作为产物：
  描述：

  甲氧苯胺 、 α-bromoacetophenone oxime 以 乙醇 为溶剂， 反应 6.0h， 以97%的产率得到(NZ)-N-[2-(N-[(2Z)-2-hydroxyimino-2-phenylethyl]-4-methoxyanilino)-1-phenylethylidene]hydroxylamine
  参考文献：
  名称：

  Beckmann Fragmentation of Diphenylcarbamoylated N-Aryldiphenacylamine Dioximes. New Method for the Synthesis of Imidazooxadiazolones

  摘要：

  N-Aryl-N,N-diphenacylamine dioximes were prepared by the reaction of corresponding arylamines with alpha-bromoacetophenone oxime in ethanol-water at room temperature. These compounds reacted with aryl isocyanates in acetonitrile to give imidazooxadiazolones 9. The probable mechanism of the reaction is discussed.

  DOI：

  10.1080/00397919908085909

文献信息

• Beckmann Fragmentation of Diphenylcarbamoylated N-Aryldiphenacylamine Dioximes. New Method for the Synthesis of Imidazooxadiazolones
  作者：Necdet Coşkun、Fatma Tirli Tat、Özden Özel Güven

  DOI：10.1080/00397919908085909

  日期：1999.11

  N-Aryl-N,N-diphenacylamine dioximes were prepared by the reaction of corresponding arylamines with alpha-bromoacetophenone oxime in ethanol-water at room temperature. These compounds reacted with aryl isocyanates in acetonitrile to give imidazooxadiazolones 9. The probable mechanism of the reaction is discussed.