(2S)-2-amino-5-[hydroxy(phenyl)phosphoryl]oxy-5-oxopentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-5-[hydroxy(phenyl)phosphoryl]oxy-5-oxopentanoic acid
• 化学式: C₁₁H₁₄NO₆P
• 分子量: 287.21
• InChiKey: IWBWKCCGHOCESA-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  127
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• ORGAN PROTECTION IN PSMA-TARGETED RADIONUCLIDE THERAPY OF PROSTATE CANCER
  申请人：Molecular Insight Pharmaceuticals, Inc.

  公开号：EP3193914A1

  公开（公告）日：2017-07-26
• [EN] METHODS FOR TREATING CANCER USING COMBINATION THERAPIES<br/>[FR] MÉTHODES POUR TRAITER LE CANCER AU MOYEN DE POLYTHÉRAPIES
  申请人：ENDOCYTE INC

  公开号：WO2014085575A1

  公开（公告）日：2014-06-05

  Described are methods, uses, and kits for utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system xc-inhibitor for the treatment of cancer or inflammation. Also described are invitro assays utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system xc- inhibitor.
• [EN] ORGAN PROTECTION IN PSMA-TARGETED RADIONUCLIDE THERAPY OF PROSTATE CANCER<br/>[FR] PROTECTION D'ORGANES DANS UNE THÉRAPIE RADIONUCLÉAIRE CIBLANT LE PSMA DU CANCER DE LA PROSTATE
  申请人：MOLECULAR INSIGHT PHARM INC

  公开号：WO2016040179A1

  公开（公告）日：2016-03-17

  A method of reducing radiation exposure of a non-cancerous tissue of a patient diagnosed with a cancer includes administering to the patient an agent capable of competing for binding sites on a surface of the non-cancerous tissue, provided that the administration is carried out after a waiting period that follows administration of a compound including a radionuclide to the patient, the compound having affinity for both a cancerous tissue and the non-cancerous tissue, and, further provided that the binding sites have an affinity for both the agent and the compound.