(1,2-Dihydroxy-4-oxoheptadecan-3-yl) tetradecanoate;propane-1,2,3-triol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (1,2-Dihydroxy-4-oxoheptadecan-3-yl) tetradecanoate;propane-1,2,3-triol
• 英文别名: (1,2-dihydroxy-4-oxoheptadecan-3-yl) tetradecanoate;propane-1,2,3-triol
• 化学式: C34H68O8
• 分子量: 604.9
• InChiKey: QSVKAKSBZRHYJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.55
• 重原子数：
  42
• 可旋转键数：
  31
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  145
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• [EN] PROSTACYCLIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS DE PROSTACYCLINE, COMPOSITIONS ET MÉTHODES D'UTILISATION ASSOCIÉES
  申请人：INSMED INC

  公开号：WO2016176555A1

  公开（公告）日：2016-11-03

  Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C2-C18 alkyl, branched C3-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described, for example, for administration via subcutaneous or intravenous infusion to a patient in need of pulmonary hypertension treatment. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom.

  本文提供了前列环素化合物和包含其的组合物。具体来说，描述了包括曲前列素与线性C2-C18烷基、支链C3-C18烷基、线性C2-C18烯基、支链C3-C18烯基、芳基、芳基-C1-C18烷基或氨基酸或肽（例如二肽、三肽、四肽）共价连接的前列环素化合物，例如，用于经皮下或静脉输注给需要肺动脉高压治疗的患者。在一个实施例中，连接是通过碳酸酯、酰胺或酯键。本文提供的前列环素化合物还可以包括至少一个氢原子被至少一个氘原子取代。
• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF SARCOIDOSIS<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE SARCOÏDOSE
  申请人：INSMED INC

  公开号：WO2017019636A1

  公开（公告）日：2017-02-02

  Compounds, methods, compositions and kits for treating a patient with pulmonary sarcoidosis are provided. The compositions are formulated for delivery to a patient in need of treatment via inhalation. In one embodiment, the method of treating pulmonary sarcoidosis in a patient in need thereof includes administering to the lungs of the patient via inhalation, a composition comprising an effective amount of a disease-modifying antisarcoid compound, a prodrug thereof, or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable inhalation excipient. The disease-modifying antisarcoid compound can be an immunomodulating agent, for example derivatives of mycophenolic acid, or a TNF-α antagonist.

  本发明提供了用于治疗肺结节病患者的化合物、方法、组合物和试剂盒。所述组合物经配制后可通过吸入途径给予需要治疗的患者。在一种实施例中，治疗肺结节病的方法包括通过吸入途径向患者的肺部给予一种组合物，所述组合物包括有效量的疾病修饰性抗结节病化合物、其前药或其药学上可接受的盐和药学上可接受的吸入助剂。疾病修饰性抗结节病化合物可以是免疫调节剂，例如麦考酚酸衍生物或TNF-α拮抗剂。
• PROSTACYCLIN COMPOUNDS
  申请人：Insmed Incorporated

  公开号：EP3808731A1

  公开（公告）日：2021-04-21

  Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.

  本文提供了前列环素化合物和包含前列环素化合物的组合物。具体而言，描述了前列环素化合物，该化合物包含与线性 C5-C18 烷基、支链 C5-C18 烷基、线性 C2-C18 烯基、支链 C3-C18 烯基、芳基、芳基-C1-C18 烷基或氨基酸或肽（如二肽、三肽、四肽）共价连接的曲普瑞替尼。在一个实施方案中，连接是通过氨基甲酸酯、酰胺或酯键。本文提供的前列环素化合物还可以包括至少一个被至少一个氘原子取代的氢原子。还提供了治疗肺动脉高压（如肺动脉高压）和门肺动脉高压的方法。
• Prostacyclin compounds, compositions and methods of use thereof
  申请人：Insmed Incorporated

  公开号：US10010518B2

  公开（公告）日：2018-07-03

  Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.

  本文提供了前列环素化合物和包含前列环素化合物的组合物。具体而言，描述了前列环素化合物，该化合物包含与线性 C5-C18 烷基、支链 C5-C18 烷基、线性 C2-C18 烯基、支链 C3-C18 烯基、芳基、芳基-C1-C18 烷基或氨基酸或肽（如二肽、三肽、四肽）共价连接的曲普瑞替尼。在一个实施方案中，连接是通过氨基甲酸酯、酰胺或酯键。本文提供的前列环素化合物还可以包括至少一个被至少一个氘原子取代的氢原子。还提供了治疗肺动脉高压（如肺动脉高压）和门肺动脉高压的方法。
• PROSTACYLIN COMPOSITIONS AND METHODS FOR USING THE SAME
  申请人：Insmed Incorporated

  公开号：EP2925303A1

  公开（公告）日：2015-10-07