(2S)-2-amino-N-[(1R)-1-[(2-methylpropan-2-yl)oxy]-2-[4-[(2-methylpropan-2-yl)oxy]phenyl]ethyl]butanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-N-[(1R)-1-[(2-methylpropan-2-yl)oxy]-2-[4-[(2-methylpropan-2-yl)oxy]phenyl]ethyl]butanamide
• 化学式: C₂₀H₃₄N₂O₃
• 分子量: 350.5
• InChiKey: CUHKGIZYZGQPHT-DLBZAZTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Process of Preparing Guanylate Cyclase C Agonists
  申请人：Bai Juncai

  公开号：US20140155575A1

  公开（公告）日：2014-06-05

  The invention provides processes of preparing a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-249 described herein.

  该发明提供了制备包括从本文所述的SEQ ID NOs：1-249中选择的GCC激动剂序列的肽的过程。
• ULTRA-PURE AGONISTS OF GUANYLATE CYCLASE C, METHOD OF MAKING AND USING SAME
  申请人：SYNERGY PHARMACEUTICALS, INC.

  公开号：US20160145307A1

  公开（公告）日：2016-05-26

  The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.

  本发明提供了一种从本文描述的SEQ ID NOs:1-251所选的包含GCC激动剂序列的肽的纯化过程。该过程包括在冷冻干燥（冻干）步骤之前进行溶剂交换步骤。
• Ultra-pure agonists of guanylate cyclase C, method of making and using same
  申请人：Synergy Pharmaceuticals, Inc.

  公开号：US10011637B2

  公开（公告）日：2018-07-03

  The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described herein. The processes include a solvent exchange step before a freeze-drying (lyophilization) step.

  本发明提供了纯化包括选自本文所述 SEQ ID NOs: 1-251 所组成的组的 GCC 激动剂序列的多肽的工艺。这些工艺包括冷冻干燥（冻干）步骤之前的溶剂交换步骤。
• PROCESS OF PREPARING GUANYLATE CYCLASE C AGONISYS
  申请人：Synergy Pharmaceuticals Inc.

  公开号：US20170129925A1

  公开（公告）日：2017-05-11

  The invention provides processes of preparing a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-249 described herein.
• US9580471B2
  申请人：——

  公开号：US9580471B2

  公开（公告）日：2017-02-28