F-DL-Val-N(Me)Leu-Ala-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: F-DL-Val-N(Me)Leu-Ala-OH
• 英文别名: (2S)-2-[[(2S)-2-[[2-(fluoroamino)-3-methylbutanoyl]-methylamino]-4-methylpentanoyl]amino]propanoic acid
• 化学式: C₁₅H₂₈FN₃O₄
• 分子量: 333.4
• InChiKey: LECLYWFKOPJLBN-NDQFZYFBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  98.7
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] NOVEL [N-ME-4-HYDROXYLEUCINE]-9-CYCLOSPORIN ANALOGUES<br/>[FR] NOUVEAUX ANALOGUES DE [N-ME-4-HYDROXYLEUCINE]-9-CYCLOSPORINE
  申请人：ENANTA PHARM INC

  公开号：WO2014085623A1

  公开（公告）日：2014-06-05

  The present invention relates to novel cyclosporine analogues having antiviral activity against HCV and useful in the treatment of HCV infections. More particularly, the invention relates to novel cyclosporine analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds.