1-[(2R)-2-amino-3-methylpentanoyl]oxyethyl (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[(2R)-2-amino-3-methylpentanoyl]oxyethyl (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylate
• 化学式: C₂₀H₃₅N₅O₉
• 分子量: 489.5
• InChiKey: FEYDKNQZQHTAFX-PKLWQMPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  242
• 氢给体数：
  7
• 氢受体数：
  11

文献信息

• PRODRUGS OF NEURAMINIDASE INHIBITORS
  申请人：SineVir Therapeutics LLC

  公开号：EP2276479B1

  公开（公告）日：2014-07-02
• Prodrugs of Neuraminidase Inhibitors
  申请人：Hilfinger John

  公开号：US20140155350A1

  公开（公告）日：2014-06-05

  A new class of neuramidase inhibitor prodrugs is provided characterized by a prodrug moiety of a carboxyl group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide or a carbonyl ethoxy tripeptide, a guanidine group modified to form a carbonyl ethoxy amino acid, a carbonyl ethoxy dipeptide, a carbonyl ethoxy tripeptide; a primary alcohol modified to form an esterified single amino acid, dipeptide or tripeptide of zanavimir of the unaltered therapeutic agent. Exemplary therapeutic agents so modified to form prodrugs include zanavimir, oseltamivir and peramivir. The prodrug has increased oral bioavailability relative to the unaltered neuraminidase inhibitor and is effective in the inhibition of viral infections involving neuraminidase in the viral reproductive cycle.
• US9181281B2
  申请人：——

  公开号：US9181281B2

  公开（公告）日：2015-11-10