3-[2-[2-(2-ethoxyethoxy)ethoxy]ethoxy]-N-methylpropanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[2-[2-(2-ethoxyethoxy)ethoxy]ethoxy]-N-methylpropanamide
• 化学式: C₁₂H₂₅NO₅
• 分子量: 263.33
• InChiKey: RVTMVIKCTXIPNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Conjugates of Pyrrolo[1,4]Benzodiazepine Dimers As Anticancer Agents
  申请人：Sanofi

  公开号：US20140155590A1

  公开（公告）日：2014-06-05

  The present invention relates to pyrrolo[1,4]benzodiazepine (PBD) dimer conjugates, to the compositions comprising them and to their therapeutic application, in particular as anticancer agents. The invention also relates to the process for the preparation of the conjugates, to their application as anticancer agents and to the dimers themselves.

  本发明涉及吡咯并[1,4]苯二氮平（PBD）二聚物偶联物，以及包含它们的组合物和它们的治疗应用，特别是作为抗癌剂。本发明还涉及制备偶联物的过程，它们作为抗癌剂的应用以及二聚体本身。
• ANTIBODY DRUG CONJUGATE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USES THEREOF
  申请人：XDCEXPLORER (SHANGHAI) CO., LTD.

  公开号：US20180161446A1

  公开（公告）日：2018-06-14

  Disclosed are an antibody drug conjugate IB, which uses ether linkages for connection, and improves the water solubility, stability and cytotoxicity in vivo and in intro, and an intermediate, a pharmaceutical composition, and uses of the antibody drug conjugate. The antibody drug conjugate has simple synthetic steps and a high yield.