(3S)-3-amino-4-[[(2S)-3-carboxy-1-[[(1R)-1-carboxy-2-(2-formyloxyethyldisulfanyl)ethyl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S)-3-amino-4-[[(2S)-3-carboxy-1-[[(1R)-1-carboxy-2-(2-formyloxyethyldisulfanyl)ethyl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
• 化学式: C₁₄H₂₁N₃O₁₀S₂
• 分子量: 455.5
• InChiKey: IWWWQYZDDHVXGT-CIUDSAMLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  273
• 氢给体数：
  6
• 氢受体数：
  13

文献信息

• Methods for treating cancer using combination therapies
  申请人：Endocyte, Inc.

  公开号：US10010618B2

  公开（公告）日：2018-07-03

  Described are methods, uses, and kits for utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system xc− inhibitor for the treatment of cancer or inflammation. Also described are in vitro assays utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system xc− inhibitor.

  描述了利用靶向配体共轭物与硫醇抑制剂或系统 xc- 抑制剂结合治疗癌症或炎症的方法、用途和试剂盒。还描述了利用靶向配体共轭物与硫醇抑制剂或系统 xc- 抑制剂结合的体外试验。
• Methods For Treating Cancer Using Combination Therapies
  申请人：ENDOCYTE, INC.

  公开号：US20140154702A1

  公开（公告）日：2014-06-05

  Described are methods, uses, and kits for utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system x c − inhibitor for the treatment of cancer or inflammation. Also described are in vitro assays utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system x c − inhibitor.
• METHODS FOR TREATING CANCER USING COMBINATION THERAPIES
  申请人：Endocyte, Inc.

  公开号：US20160296630A1

  公开（公告）日：2016-10-13

  Described are methods, uses, and kits for utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system x c − inhibitor for the treatment of cancer or inflammation. Also described are in vitro assays utilizing a targeted ligand conjugate in combination with a thiol inhibitor or a system x c − inhibitor.