(5Z,9R,10E,13S)-9-[(1R)-3-chloro-1-hydroxypropyl]-13-(1-ethylcyclobutyl)-13-hydroxytrideca-5,10-dienoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5Z,9R,10E,13S)-9-[(1R)-3-chloro-1-hydroxypropyl]-13-(1-ethylcyclobutyl)-13-hydroxytrideca-5,10-dienoic acid
• 化学式: C₂₂H₃₇ClO₄
• 分子量: 401.0
• InChiKey: MPOOCOWJIDIGAR-UTEXHAGISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• COMPOUND FOR TREATING CARTILAGE DISORDERS
  申请人：ONO Pharmaceutical Co., Ltd.

  公开号：EP2740724A1

  公开（公告）日：2014-06-11

  The present invention provides a compound of which active form is represented by a formula (A). and which can be injected into a joint cavity which is an affected part of disorders and can be accumulated in the joint cavity to exert the pharmacological effect thereof in a sustained manner, for the purpose of ameliorating cartilage disorders without developing any side effect. A compound according to the present invention, which is represented by a formula (I): (wherein all of symbols are as defined in the description), is a compound that can achieve the above-mentioned purpose. This compound does not exhibit any side effect on the cardiovascular system even when the compound is administered in an effective amount for exhibiting a cartilage regeneration activity, and is therefore extremely useful as a safe and effective preventive and/or therapeutic agent for cartilage disorders. Since a suspension produced using this compound can be injected without requiring the incision of the affected part, it can reduce the burden on patients, and is extremely useful as a medicinal agent.

  本发明提供了一种化合物，其活性形式由式(A)表示，可注射到受疾病影响的关节腔内，并可在关节腔内蓄积，以持续发挥其药理作用，从而达到改善软骨疾病而不产生任何副作用的目的。根据本发明的一种化合物，由式（I）表示： (其中所有符号如描述中所定义）表示的化合物，可以达到上述目的。该化合物即使以有效量施用也不会对心血管系统产生任何副作用，从而显示出软骨再生活性，因此作为一种安全有效的软骨疾病预防和/或治疗剂极为有用。由于使用该化合物生产的混悬液无需切开患病部位即可注射，因此可以减轻患者的负担，作为一种药物非常有用。