[(2S)-1-[[(2R)-1,5-dihexadecoxy-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-3-ium-2-yl)-1-oxopropan-2-yl]azanium;dichloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(2S)-1-[[(2R)-1,5-dihexadecoxy-1,5-dioxopentan-2-yl]amino]-3-(1H-imidazol-3-ium-2-yl)-1-oxopropan-2-yl]azanium;dichloride
• 化学式: C43H82Cl2N4O5
• 分子量: 806.0
• InChiKey: ASAFTSIHBFWJOY-ZHUVULQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  54
• 可旋转键数：
  40
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  139
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] HISTIDINYLATED CATIONIC AMPHIPHILES, PROCESS FOR PREPARATION THEREOF AND THEIR LIPOSOMAL FORMULATION<br/>[FR] AMPHIPHILES CATIONIQUES HISTIDINYLÉS, PROCÉDÉ DE PRÉPARATION ASSOCIÉ ET FORMULATION EN LIPOSOME ASSOCIÉE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2014087429A1

  公开（公告）日：2014-06-12

  Novel anti-cancer reagents capable of combating various types of tumors continue to be major research focus in many leading pharmaceutical companies round the globe. To this end, the present invention discloses processes for preparing a novel series of histidinylated cationic amphiphiles of formula I. The findings described herein also demonstrate that compounds of the present invention possess anti-proliferative activity such as anti" cancer activity and are useful in combating various types of cancer. The pharmaceutically active composition of cationic amphiphiles disclosed herein show enhanced cellular apoptosis through the Bax & Bcl-2 mediated signal transduction pathway. Cationic amphiphiles with histidine head-groups described in the present invention are likely to find future applications in the field of anti-cancer therapy.

  新型抗癌试剂能够对抗各种类型的肿瘤，继续成为全球许多领先制药公司的主要研究重点。为此，本发明揭示了制备一系列新型组氨酸化阳离子两性分子的方法，其化学式为I。本文所述的研究结果还表明，本发明的化合物具有抗增殖活性，如抗癌活性，并且在对抗各种类型的癌症中具有用途。本文披露的带有组氨酸头基的阳离子两性分子的药用活性组合物通过Bax和Bcl-2介导的信号转导途径显示出增强的细胞凋亡作用。本发明中描述的带有组氨酸头基的阳离子两性分子可能在抗癌疗法领域找到未来的应用。
• HISTIDINYLATED CATIONIC AMPHIPHILES, PROCESS FOR PREPARATION THEREOF AND THEIR LIPOSOMAL FORMULATION
  申请人：Council of Scientific & Industrial Research

  公开号：EP2928871A1

  公开（公告）日：2015-10-14
• HISTIDINYLATED CATIONIC AMPHIPHILES, PROCESS FOR PREPARATION THEROF AND THEIR LIPOSOMAL FORMULATION
  申请人：COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

  公开号：US20150315154A1

  公开（公告）日：2015-11-05

  Novel anti-cancer reagents capable of combating various types of tumors continue to be major research focus in many leading pharmaceutical companies round the globe. To this end, the present invention discloses processes for preparing a novel series of histidinylated cationic amphiphiles of formula I. The findings described herein also demonstrate that compounds of the present invention possess anti-proliferative activity such as anti” cancer activity and are useful in combating various types of cancer. The pharmaceutically active composition of cationic amphiphiles disclosed herein show enhanced cellular apoptosis through the Bax & Bcl-2 mediated signal transduction pathway. Cationic amphiphiles with histidine head-groups described in the present invention are likely to find future applications in the field of anti-cancer therapy.