(2R)-2,5,6-triamino-6-oxohexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2,5,6-triamino-6-oxohexanoic acid
• 化学式: C₆H₁₃N₃O₃
• 分子量: 175.19
• InChiKey: QNWREZKNSMXBKY-SRBOSORUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• REGULATING BACILLUS ANTHRACIS LETHAL FACTOR ACTIVITY VIA AN ACTIVATING EPITOPE REGION
  申请人：The United States of America, as represented by The Secretary, Health and Human Services

  公开号：EP2895857A2

  公开（公告）日：2015-07-22
• [EN] REGULATING BACILLUS ANTHRACIS LETHAL FACTOR ACTIVITY VIA AN ACTIVATING EPITOPE REGION<br/>[FR] RÉGULATION DE L'ACTIVITÉ DU FACTEUR LÉTHAL DE BACILLUS ANTHRACIS PAR L'INTERMÉDIAIRE D'UNE RÉGION ÉPITOPE ACTIVATRICE
  申请人：CENTERS DISEASE CONTROL & PREVENTION

  公开号：WO2014088664A2

  公开（公告）日：2014-06-12

  Provided are peptides capable of reducing the ability of antibodies to stimulate the activity of B. anthracis lethal factor. These peptides may be used to reduce activity of LF in a sample containing an LF activity enhancing antibody, to prevent the possibility of LF enhanced activity in a sample or subject, or as a therapeutic to reduce LF activity in a subject that may- have one or more antibodies that enhance LF activity. Also, provided are immunogens that may be used in a vaccine to confer protection to a subject. An immunogen does not include a sequence including the wild-type amino acids present in LF residues 677-680, or mutations of amino acids 677-680 that will also generate antibodies that enhance LF activity.