3-[2-(2-Chloro-3,6-difluorophenyl)ethoxy]-2-nitropyridine

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 3-[2-(2-Chloro-3,6-difluorophenyl)ethoxy]-2-nitropyridine
• 英文别名: 3-[2-(2-chloro-3,6-difluorophenyl)ethoxy]-2-nitropyridine
• 化学式: C13H9ClF2N2O3
• 分子量: 314.67
• InChiKey: OIDITMFIQNPENR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  67.9
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS CYCLIQUES SUBSTITUÉS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：CALITOR SCIENCES LLC

  公开号：WO2014089324A1

  公开（公告）日：2014-06-12

  The present invention provides novel substituted alkynyl compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

  本发明提供了新颖的取代炔基化合物，药用可接受的盐及其制剂，用于调节蛋白酪氨酸激酶活性，并调节细胞活动，如增殖、分化、凋亡、迁移和侵袭。该发明还提供了包括这些化合物的药用可接受的组合物，以及在治疗哺乳动物，特别是人类的增生性疾病中使用这些组合物的方法。
• [EN] SUBSTITUTED PYRIDINE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS DE PYRIDINE SUBSTITUÉE ET LEURS MÉTHODES D'UTILISATION
  申请人：CALITOR SCIENCES LLC

  公开号：WO2015034729A1

  公开（公告）日：2015-03-12

  The present invention provides novel substituted pyridine compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.