(S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(1S,9S,10S)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 金鸡纳生物碱
• 英文名称: (S)-[(2R,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;(1S,9S,10S)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
• 化学式: C37H47N3O3
• 分子量: 581.8
• InChiKey: RPNGLNIRUUQKBY-ZEVJXOESSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.25
• 重原子数：
  43
• 可旋转键数：
  4
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL DEPSIPEPTIDE AND USES THEREOF
  申请人：Novobiotic Pharmaceuticals, LLC

  公开号：EP2925772A1

  公开（公告）日：2015-10-07
• [EN] NOVEL DEPSIPEPTIDE AND USES THEREOF<br/>[FR] NOUVEAU DEPSIPEPTIDE ET SES UTILISATIONS
  申请人：NOVOBIOTIC PHARMACEUTICALS LLC

  公开号：WO2014089053A1

  公开（公告）日：2014-06-12

  The present invention relates generally to novel depsipeptides, to methods for the preparation of these novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides to treat or inhibit various disorders.