[(2R,3R)-2-[(S)-[2,4-dioxo-3-[[6-(trifluoromethoxy)-1,2-benzoxazol-3-yl]methyl]pyrimidin-1-yl]-hydroxymethoxy]-3-hydroxybutyl] phosphono hydrogen phosphate

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: [(2R,3R)-2-[(S)-[2,4-dioxo-3-[[6-(trifluoromethoxy)-1,2-benzoxazol-3-yl]methyl]pyrimidin-1-yl]-hydroxymethoxy]-3-hydroxybutyl] phosphono hydrogen phosphate
• 化学式: C₁₈H₂₀F₃N₃O₁₄P₂
• 分子量: 621.3
• InChiKey: JNAGGECAGBCYHT-AEYAVQINSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  239
• 氢给体数：
  5
• 氢受体数：
  18

文献信息

• URIDINE DIPHOSPHATE DERIVATIVES, PRODRUGS, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISORDERS
  申请人：Tufts University

  公开号：US20140162972A1

  公开（公告）日：2014-06-12

  This disclosure relates to prodrugs of uridine diphosphate (UDP) derivatives, compositions comprising therapeutically effective amounts of those prodrugs of the UDP derivatives and methods of using those prodrugs or compositions in treating disorders that are responsive to ligands, such as agonists, of P 2 Y 6 receptor, e.g., neuronal disorders, including neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease) and traumatic CNS injury, pain, Down Syndrome (DS), glaucoma, and inflammatory conditions.
• US9163055B2
  申请人：——

  公开号：US9163055B2

  公开（公告）日：2015-10-20